The Association Between Arsenic Levels and Oxidative Stress in Myocardial Infarction: A Case–Control Study

• Published in: Cardiovascular toxicology 2023, Vol.23 (1), p.61-73
• Main Authors: Sagha, Arian, Shiri, Hamidreza, Juybari, Kobra Bahrampour, Mehrabani, Mehrnaz, Nasri, Hamid Reza, Nematollahi, Mohammad Hadi
• Format: Article
• Language: English
• Subjects: Angiography; Antioxidants; Arsenic; Arsenic - adverse effects; Arteriosclerosis; Atherosclerosis; Biomedical and Life Sciences; Biomedicine; Cardiology; Cardiovascular diseases; Cardiovascular system; Case-Control Studies; Cholesterol, LDL; Coronary artery; Coronary vessels; Creatinine; Cytotoxicity; Evaluation; Heart attacks; Heavy metals; High density lipoprotein; Humans; Low density lipoprotein; Myocardial infarction; Myocardial Infarction - epidemiology; Oxidative Stress; Patients; Pharmacology/Toxicology; Risk analysis; Risk Factors; Urea
• ISSN: 1530-7905; 1559-0259
• DOI: 10.1007/s12012-022-09778-y

Cardiovascular diseases (CVDs) are known as the first causes of death throughout the world, and mainly myocardial infarction (MI), lead to 7.4 million deaths annually. Atherosclerosis is the major underlying cause of most CVDs. However, exposure to heavy metals, among other factors, deserves further attention as a risk factor for CVDs. This study was designed to evaluate the levels of arsenic (Ars) in myocardial infarction (MI) patients and healthy individuals as well as assess the association between the incidence of MI and Ars, total antioxidant capacity (TAC), and oxidative stress. This case–control study was conducted among patients with MI ( n = 164) and normal individuals ( n = 61) at Shafa Hospital in Kerman, Iran. Patients were classified into two groups, including coronary artery blocks above 50% (CAB > 50%, n = 83) and coronary artery blocks less than 50% (CAB < 50%, n = 83) based on their angiography findings. The demographic characteristics, clinical history, biochemical parameters, and serum Ars and TAC levels were evaluated. In the present study, both CAB groups had significantly reduced levels of TAC compared with the control. Furthermore, TAC was lower in the CAB > %50 group compared to the CAB < %50 group. Ars levels were significantly higher in both CAB groups compared with the control. There was a significant positive relationship between CAB and Ars, BG, HbA 1 c, urea, creatinine, TG, TC, and LDL-c, as well as a negative relationship between HDL-c and TAC. Moreover, TAC levels showed a significant inverse correlation with Ars, HbA 1 c, and creatinine, and a positive correlation with HDL-c. As risk factors, Ars, hs-CRP, TG, TC, and LDL-c enhance the severity of the disease, and HDL-c and TAC decrease the disease severity. Moreover, ROC curve analysis revealed that the highest AUC for the CAB > %50 (AUC = 78.29), and cytotoxic levels for both CAB groups (Ars ≥ 0.105 ppm), and no significant differences were found between the two groups. Our findings suggest that Ars at ≥ 0.105 ppm is able to increase the risk of MI through the increased OS and decreased TAC.