Polysaccharides from macro algae: Anti-inflammatory actions against systemic inflammatory process and in the gastrointestinal tract

Sulfated polysaccharides (PLS) extracted from marine algae have important biological activities in different inflammatory models. They consist of a diverse group with great potential for discovering molecules with pharmacological and biotechnological properties, formed by heterogeneous macromolecule...

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Bibliographic Details
Published in:Journal of applied phycology 2023-02, Vol.35 (1), p.381-395
Main Authors: de Sousa, Antônio Kleiton, Araujo, Anna Sofia Miranda Loiola, da Silva, Tino Marcos Lino, de Sousa de Lima, Fernando Mesquita, dos Santos Ferreira, Jayro, de Brito, Tarcisio Vieira, dos Reis Barbosa, André Luiz
Format: Article
Language:English
Subjects:
Algae
Biomedical and Life Sciences
Biotechnology
Cell adhesion & migration
Cell migration
Chemical composition
Cytokines
Dietary minerals
Ecology
Edema
Freshwater & Marine Ecology
Galactans
Galactose
Gastrointestinal system
Gastrointestinal tract
Inflammation
Inflammatory bowel disease
Injury prevention
Large intestine
Life Sciences
Macromolecules
Marine biology
Oxidative stress
Pain perception
Plant Physiology
Plant Sciences
Polysaccharides
Saccharides
Seaweeds
Systematic review
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Summary:Sulfated polysaccharides (PLS) extracted from marine algae have important biological activities in different inflammatory models. They consist of a diverse group with great potential for discovering molecules with pharmacological and biotechnological properties, formed by heterogeneous macromolecules rich in galactose and characterized by the presence of sulfated groups in their chemical composition. Several studies using marine algae PLSs in inflammatory pathologies in different experimental models have demonstrated the anti-inflammatory effects of these molecules, showing the reduction of oxidative stress parameters, cell migration, pro-inflammatory cytokines, macroscopic and microscopic criteria of tissue injury, in addition to of reduced nociception. In this sense, the present study aimed to determine the effects of sulfated polysaccharides from seaweeds, especially galactans, during general and gastrointestinal tract (GIT) inflammation through a systematic review.
ISSN:0921-8971
1573-5176
DOI:10.1007/s10811-022-02878-w