Ir‐Catalyzed Transfer Hydrogenation and Alkylation of Aldehydes and Ketones Using Ethanol as the Hydrogen Source

Bio‐derived ethanol is a promising green and sustainable hydrogen‐donor solvent. Herein, we have developed Ir‐catalyzed transfer hydrogenation of ketones and aldehydes using ethanol as a hydrogen source with amides as simple ligands. Furthermore, the alkylation of ketones and tandem alkylation/trans...

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Bibliographic Details
Published in:European journal of organic chemistry 2023-02, Vol.26 (5), p.n/a
Main Authors: Yadav, Suman, Rao Kuram, Malleswara
Format: Article
Language:English
Subjects:
Aldehydes
Alkylation
Amides
Ethanol
Hydrogenation
Ketones
reduction
transfer hydrogenation
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Summary:Bio‐derived ethanol is a promising green and sustainable hydrogen‐donor solvent. Herein, we have developed Ir‐catalyzed transfer hydrogenation of ketones and aldehydes using ethanol as a hydrogen source with amides as simple ligands. Furthermore, the alkylation of ketones and tandem alkylation/transfer hydrogenation of acetophenones is reported with ethanol. Ethanol is used as a hydrogen source and an alkylating agent in the Ir‐catalyzed transfer hydrogenation and alkylation of ketones and aldehydes with amides as simple ligands affording alcohols in good to excellent yields. Our studies revealed the significant role of the base in achieving the TH and alkylation of carbonyl compounds with ethanol. The control experiments indicated the formation of Ir−H species and the important role of ligand in stabilizing the metal complex.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202201344