Lessons Learned from the ISCHEMIA Trial for the Management of Patients with Stable Ischemic Heart Disease

The recent landmark International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial was undertaken to assess whether stable angina patients with moderate to severe baseline ischemia would benefit from an invasive approach with revascularization versus a...

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Bibliographic Details
Published in:Annual review of medicine 2023-01, Vol.74 (1), p.189-198
Main Authors: Boden, William E, Stone, Peter H
Format: Article
Language:English
Subjects:
Angina
Cardiovascular disease
Heart diseases
Humans
invasive and conservative approaches
Ischemia
Ischemia - complications
myocardial ischemia
Myocardial Ischemia - therapy
Myocardial Revascularization
optimal medical therapy
Patients
stable angina
Treatment Outcome
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Summary:The recent landmark International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial was undertaken to assess whether stable angina patients with moderate to severe baseline ischemia would benefit from an invasive approach with revascularization versus a conservative approach of intensive lifestyle intervention and pharmacologic secondary prevention. This trial addressed the hypothesis that treating ischemia with an invasive approach would reduce major adverse cardiac events more than a noninvasive pharmacologic and lifestyle approach. ISCHEMIA is discussed in detail, along with current implications for contemporary management of this very common cardiac disorder afflicting millions of patients worldwide.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev-med-042921-124013