Hepatoprotective Effects of Taurine Against Cadmium-Induced Liver Injury in Female Mice

• Published in: Biological trace element research 2023-03, Vol.201 (3), p.1368-1376
• Main Authors: Zheng, Jiaming, Qiu, Guobin, Zhou, Yewen, Ma, Kezhe, Cui, Sheng
• Format: Article
• Language: English
• Subjects: Animal health; Animals; Antioxidants - metabolism; Apoptosis; BAX protein; Bcl-2 protein; Biochemistry; Biomarkers; Biomedical and Life Sciences; Biotechnology; Body Weight; Cadmium; Cadmium - pharmacology; Caspase-3; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - metabolism; Chemical and Drug Induced Liver Injury - prevention & control; Chemical and Drug Induced Liver Injury, Chronic - metabolism; Contaminants; Cristae; Degeneration; Female; Heavy metals; Hepatocytes; Hepatotoxicity; Humans; Inflammation; Life Sciences; Liver; Liver - metabolism; Lysis; Mice; Mitochondria; Nutrition; Oncology; Oxidative Stress; Serum; Taurine; Taurine - pharmacology; Toxicity; Toxins; Tumor necrosis factor-α; Ultrastructure
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-022-03252-0

Cadmium (Cd), a heavy metal contaminant, seriously threatens human and animal health. Taurine (Tau) has been used against hepatotoxicity caused by different environmental toxins. However, it has not been elucidated whether Tau exerts its protective function against Cd-induced hepatotoxicity. The aim of this study was thus to evaluate the ameliorative function of Tau (500 mg/kg body weight intraperitoneally) on Cd-induced (2 mg/kg body weight intraperitoneally) liver toxicity in mice for 14 days. The histopathologic and ultrastructure changes as well as alterations in indexes related to liver function, antioxidant biomarkers, inflammatory, and apoptosis were evaluated. The results showed that Tau alleviated the vacuolar degeneration, nuclear condensation, mitochondria swelling, and cristae lysis of hepatocytes induced by Cd. In addition, Tau treatment significantly reduced the ALT, AST levels in serum, and inflammatory factor TNF-α and IL-1β in liver tissue. Furthermore, Tau treatment decreased the Bax/Bcl-2 ratio and cleaved caspase-3 protein expression levels. Taken together, these observations demonstrate that Tau has an important hepatic protective function against the inflammation and apoptosis induced by Cd.