The association of phthalate metabolites with childhood waist circumference and abdominal obesity

The association between phthalates exposure and childhood abdominal obesity is still unclear. This study aimed to assess phthalates (PAEs) exposure level and explore the association between PAEs metabolites exposure and the risk of abdominal obesity in Chinese students aged 7–10 years. A total of 79...

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Bibliographic Details
Published in:European journal of pediatrics 2023-02, Vol.182 (2), p.803-812
Main Authors: Wang, Zheng-he, Gao, Di, Zou, Zhi-yong
Format: Article
Language:English
Subjects:
Abdomen
Adolescent
Asian students
Blood pressure
Child
Childhood
Children
Children & youth
Creatinine
Cross-sectional studies
Endocrine disruptors
Environmental Exposure - adverse effects
Environmental Exposure - analysis
Environmental factors
Female
High-performance liquid chromatography
Humans
Male
Mass spectroscopy
Medicine
Medicine & Public Health
Metabolites
Obesity
Obesity, Abdominal - diagnosis
Obesity, Abdominal - epidemiology
Obesity, Abdominal - etiology
Pediatric Obesity - diagnosis
Pediatric Obesity - epidemiology
Pediatric Obesity - etiology
Pediatrics
Phthalic Acids - analysis
Phthalic Acids - chemistry
Phthalic Acids - metabolism
Students
Waist Circumference
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Summary:The association between phthalates exposure and childhood abdominal obesity is still unclear. This study aimed to assess phthalates (PAEs) exposure level and explore the association between PAEs metabolites exposure and the risk of abdominal obesity in Chinese students aged 7–10 years. A total of 798 students aged 7–10 years were selected from the baseline survey of the cohort of Childhood Blood Pressure and Environmental Factors (CBPEF), which was established in Xiamen City, Fujian province, East China, from August to November in 2018. Urine samples were collected from these students to analyze the concentrations of seven PAEs metabolites using the method of high-performance liquid chromatography–tandem triple quadrupole mass spectrometry. Waist circumference was used to define abdominal obesity. The logistic regression model was used to analyze the association of urinary creatinine-adjusted PAEs metabolites with childhood abdominal obesity risk. The prevalence of childhood abdominal obesity is 12.0% (96/798). Apart from mono(2-ethylhexyl) phthalate (62.5% for boys and 47.0% for girls), the detection rate of the others PAEs metabolites ranged from 82.6 to 100%. Boys had higher concentrations of PAEs metabolites than girls ( P  
ISSN:1432-1076
0340-6199
1432-1076
DOI:10.1007/s00431-022-04751-x