Serum protein S-100B as a novel biomarker of diagnosis and prognosis of childhood epilepsy

BackgroundElevated levels of S-100B in serum are increasingly considered a potential biochemical marker of nervous system damage. To our knowledge, limited number of research studies have tested the serum S-100B protein levels in children with epilepsy. The objective of our study is to measure the s...

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Bibliographic Details
Published in:The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Psychiatry and Neurosurgery, 2023-02, Vol.59 (1), p.19-6
Main Authors: Khamis, Mohamed, Din, Nahed Salah El, Nada, Maha Ali, Afifi, Hossam El Din Mahmoud
Format: Article
Language:English
Subjects:
Biological marker
Biomarkers
Brain research
Childhood
Childhood epilepsy
Children
Convulsions & seizures
Epilepsy
Nervous system
Outpatient care facilities
Pathogenesis
Patients
Pediatrics
Proteins
Psychiatry
S-100B level
Variance analysis
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Summary:BackgroundElevated levels of S-100B in serum are increasingly considered a potential biochemical marker of nervous system damage. To our knowledge, limited number of research studies have tested the serum S-100B protein levels in children with epilepsy. The objective of our study is to measure the serum levels of S-100B protein in pediatric cases with epilepsy.ResultsThe mean serum concentration of S-100B protein was 0.135 ± 0.014 mg/L in the patient group and 0.082 ± 0.018 mg/L in the control group. The patients showed significantly high S-100B protein levels compared with healthy controls (P 
ISSN:1110-1083
1687-8329
DOI:10.1186/s41983-023-00605-x