Intermediate uveitis associated with Cogan's syndrome

Purpose: To describe a case of intermediate uveitis and optic neuritis associated with Cogan's syndrome. Methods: A case report. Results: A 29‐year‐old white Caucasian female was referred to our department for decreased vision in her left eye (LE). Previous medical history revealed relapsing in...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2022-12, Vol.100 (S275), p.n/a
Main Authors: El Mayel, Amina, Amor, Hager Ben, Sellem, Ilhem, Mesfar, Rahma, Khochtali, Sana, Ksiaa, Imen, Khairallah, Moncef
Format: Article
Language:English
Subjects:
Acuity
Anterior chamber
Antineutrophil cytoplasmic antibodies
Antinuclear antibodies
Atrophy
Autoimmune diseases
Azathioprine
Cornea
Eye
Hearing loss
Infectious diseases
Inflammation
Neuritis
Optic neuritis
Prednisone
Rheumatoid factor
Sensory neurons
Uveitis
Vasculitis
Vestibular system
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Summary:Purpose: To describe a case of intermediate uveitis and optic neuritis associated with Cogan's syndrome. Methods: A case report. Results: A 29‐year‐old white Caucasian female was referred to our department for decreased vision in her left eye (LE). Previous medical history revealed relapsing intermediate uveitis and optic neuritis in the LE for 5 years and a sensio‐neural hearing loss a year earlier. On presentation, her ophthalmological examination revealed best corrected visual acuity in the LE of 6/60 with a relative afferent pupillary defect. Slit lamp examination revealed a clear cornea, 0.5+ cells in the anterior chamber and 3+ cells in the vitreous. Fundus examination showed an optic disc atrophy. Examination of the right eye was unremarkable. Examination by the internist revealed palmar erythematous lesions. Laboratory work‐up was negative for infectious diseases. Testing for antinuclear antibodies, antineutrophil cytoplasmic antibodies and rheumatoid factor were negative. The diagnosis of atypical Cogan's syndrome was made based on the association of atypical ophthalmological manifestations and typical audio‐vestibular manifestations. The patient was treated with oral prednisone and azathioprine. Conclusions: Optic neuritis may rarely be an ocular manifestation of Cogan's syndrome.
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2022.0552