Ex vivo models of corneal epithelial regeneration in bioreactor: Respective roles of limbal, conjunctival and corneal epithelia

Purpose: The corneas preserved in bioreactor (BR) had been shown to have not only a better endothelial viability, but also a more differentiated and stratified epithelium than corneas preserved in organoculture. Purpose: By using BR, we would analyse the respective contribution of corneal (C), limba...

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Published in:Acta ophthalmologica (Oxford, England) England), 2022-12, Vol.100 (S275), p.n/a
Main Authors: He, Zhiguo, Perrache, Chantal, Poinard, Sylvain, Forest, Fabien, Aouimeur, Inès, Coulomb, Louise, Moussa, Olfa Ben, Vaitinadapoule, Hanielle, Peyret, Benjamin, Cortez, Oliver Dorado, Sagnial, Tomy, Mentek, Marielle, Crouzet, Emmanuel, Urbaniak, Sébastien, Papillon, Jean‐Marie, Maurin, Corantin, Ninotta, Sandrine, Mascarelli, Frederic, Gain, Philippe, Thuret, Gilles
Format: Article
Language:English
Subjects:
Angiogenesis
Bioreactors
Conjunctiva
Cornea
Epithelial cells
Epithelium
Immunofluorescence
Progenitor cells
Stem cells
Vascularization
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Summary:Purpose: The corneas preserved in bioreactor (BR) had been shown to have not only a better endothelial viability, but also a more differentiated and stratified epithelium than corneas preserved in organoculture. Purpose: By using BR, we would analyse the respective contribution of corneal (C), limbal (L), and conjunctival (Conj) epithelia in corneal epithelial regeneration. Methods: Five pairs of corneas from body donation to Science were used with a death‐to‐collection time 
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2022.0635