Synthesis, Antibacterial, and Antifungal Screening of New Pyrazolo[3,4-d]pyrimidine Derivatives

A series of 3-amino-4-substituted phenyl-1,4,5,7-tetrahydro-6 H -pyrazolo[3,4- d ]pyrimidin-6-imines was synthesized. In vitro antibacterial and antifungal screening indicated that some compounds show good inhibition in comparison with standard drugs amoxycillin, chloramphenicol, ciprofloxacin, norf...

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Bibliographic Details
Published in:Russian journal of general chemistry 2022-12, Vol.92 (12), p.2734-2739
Main Authors: Dubal, G. G., Vachchharajani, P. R., Solanki, M. J., Shah, V. H.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antifungal agents
Antiinfectives and antibacterials
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chloromycetin
Drug discovery
Fungicides
Imines
Norfloxacin
Pyrimidines
Resveratrol
Screening
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Summary:A series of 3-amino-4-substituted phenyl-1,4,5,7-tetrahydro-6 H -pyrazolo[3,4- d ]pyrimidin-6-imines was synthesized. In vitro antibacterial and antifungal screening indicated that some compounds show good inhibition in comparison with standard drugs amoxycillin, chloramphenicol, ciprofloxacin, norfloxacin, griseofulvin, and nystatin.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363222120234