The Possible Role of Selected Vitamins and Minerals in the Therapeutic Outcomes of Leishmaniasis

• Published in: Biological trace element research 2023-04, Vol.201 (4), p.1672-1688
• Main Authors: kumar, V Udaya, KT, Muhammed Favas, Sharma, Ayush, Bisht, Priya, Dhingra, Sameer, Ravichandiran, V., Ramesh, M., Murti, Krishna
• Format: Article
• Language: English
• Subjects: Adaptive immunity; Biochemistry; Biomedical and Life Sciences; Biotechnology; Body mass; Cell proliferation; Drug resistance; Ecological effects; Environmental factors; Health risks; Human physiology; Humans; Immunity; Infections; Iron; Leishmaniasis; Leishmaniasis - drug therapy; Life Sciences; Low income groups; Malnutrition; Micronutrients; Micronutrients - therapeutic use; Minerals; Nutrient availability; Nutrition; Oncology; Parasites; Parasitic diseases; Poverty; Proliferation; Protozoal infections; Trace elements; Trace elements (nutrients); Trace Elements - pharmacology; Treatment Outcome; Vector-borne diseases; Vitamin A; Vitamin D; Vitamin K; Vitamins; Vitamins - pharmacology; Vulnerability; Zinc; Zinc - therapeutic use
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-022-03311-6

Leishmaniasis is a protozoal disease declared as an endemic in areas suffering from severe malnutrition and poverty. The factors associated with poverty like low income, ecological factors, and malnutrition cause disruption in immunity and host defense increasing risk of infection. Altered resistance to infection and host susceptibility are associated with low micronutrient levels in undernourished patients. Malnutrition has been recognized as a poor predictive marker for leishmaniasis, in particular the deficiency of trace elements like zinc, iron, and vitamin A, B, C, D which has a prominent function in the regulation of innate and adaptive immunity, cell proliferation, human physiology, etc. Malnourishment can exacerbate host sensitivity and pathophysiologic intensity to infection in variety of ways, whereas infection can enhance underlying poor nutrition or enhance host vulnerability and sandfly's urge to attack specific hosts. The intensity of leishmaniasis can be influenced by body mass and micronutrient availability in the blood. Vitamin D, C, zinc, and iron are proved effective in inhibiting the growth of leishmaniasis in both amastigote or promastigote forms, either directly or by acting as precursor for a pathway which inhibits the parasite growth. This article elucidates a new perception to the crucial role of micronutrients and their probable role in the therapeutic outcomes of leishmaniasis. Since there is requirement of novel drugs to fight drug resistance and relapse of leishmaniasis, this article may pave way to understand the importance of micronutrients and their role in therapeutic outcomes of leishmaniasis.