Anti-neuroinflammatory sesquiterpenoids from Chloranthus henryi

Hupelactones A (1) and B (2), two new eudesmanolide-type enantiomers of the corresponding compounds, along with four mono- (3-6) and nine dimeric- (7-15) known sesquiterpenoids were isolated from the whole plant of Chloranthus henryi var. hupehensis (syn. C. henryi). The new structures including the...

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Bibliographic Details
Published in:Natural product research 2023-03, Vol.37 (6), p.882-890
Main Authors: Wang, Xue-Jiao, Xin, Jun-Li, Yu, Sheng-Zhou, Pan, Li-Long, Hu, Jin-Feng, Xiong, Juan
Format: Article
Language:English
Subjects:
Animals
anti-neuroinflammation
Chloranthaceae
Chloranthus henryi
Circular dichroism
Dichroism
Dimers
Enantiomers
Inflammation
Lipopolysaccharides
Magnoliopsida - chemistry
Mice
Microglia
Microglial cells
Molecular Structure
Nitric Oxide
Sesquiterpenes - chemistry
Sesquiterpenes - pharmacology
Sesquiterpenoids
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Summary:Hupelactones A (1) and B (2), two new eudesmanolide-type enantiomers of the corresponding compounds, along with four mono- (3-6) and nine dimeric- (7-15) known sesquiterpenoids were isolated from the whole plant of Chloranthus henryi var. hupehensis (syn. C. henryi). The new structures including the absolute configurations were determined by comparison with previously reported enantiomers, extensive spectroscopic methods in combination with electronic circular dichroism (ECD) calculations. All the isolates were evaluated for their inhibitory activities against the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in murine BV-2 microglial cells. Among them, the dimeric lindenane sesquiterpenoids shizukaols F (8) and G (11) exhibited the most potent activities, with IC 50 values of 2.65 and 4.60 μM, respectively.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2095633