Executive functions in migraine patients: a systematic review with meta-analysis

Introduction: Migraine, a common neurological disease, is known to impact the quality of life of individuals with this condition. Methods: We performed a systematic review with meta-analysis to investigate the abnormalities associated with executive functions of migraineurs as compared with healthy...

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Bibliographic Details
Published in:Cognitive neuropsychiatry 2023, Vol.28 (1), p.52-66
Main Authors: Kaiser Pinotti, Luciane, Castro, Anderson da Silva, de Oliveira Garcia, Gabriel Henrique, Alvim, Pedro Henrique Pereira, Roza, Thiago Henrique, Andrade, Fabiana Antunes, Kowacs, Pedro André, Massuda, Raffael
Format: Article
Language:English
Subjects:
Attention
Epilepsy
Executive Function
Humans
Meta-analysis
Migraine
Migraine Disorders
Quality of Life
Systematic review
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Summary:Introduction: Migraine, a common neurological disease, is known to impact the quality of life of individuals with this condition. Methods: We performed a systematic review with meta-analysis to investigate the abnormalities associated with executive functions of migraineurs as compared with healthy controls. In addition, we investigated the differences between patients with and without aura. Results: A total of 25 studies were included in the systematic review and 19 in the meta-analysis. Meta-analysis was conducted using random effects models, with the unit of analysis as the standardised mean difference (calculated as Hedges'g). Patients with migraine had worse performance in the trail making test A (g = 0.40; 95% confidence interval [CI] 0.05-0.74; p = 0.0271) and B (g = 0.40; 95% CI 0.16-0.64; p = 0.0026), and digit span backward test (g = -0.20; 95% CI - 0.31, - 0.09; p = 0.0105). Subgroup analysis revealed no difference between migraine with and without aura. Conclusion: These results suggest that migraine patients may present worse performance for specific executive functional domains, including attention, working memory, and mental flexibility.
ISSN:1354-6805
1464-0619
DOI:10.1080/13546805.2022.2149390