Microwave-assisted extract of rhodomyrtone from rhodomyrtus tomentosa leaf: Anti-inflammatory, antibacterial, antioxidant, and safety assessment of topical rhodomyrtone formulation

Series of works on the biological properties of rhodomyrtone, a major active component of Rhodomyrtus tomentosa leaf has been reported. In this study, rhodomyrtone-rich microwave-assisted extract from R. tomentosa leaf (RT-MAE) before formulation was profiled for phytochemical composition using gas...

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Bibliographic Details
Published in:Separation science and technology 2023-03, Vol.58 (5), p.929-943
Main Authors: Chorachoo Ontong, Julalak, Singh, Sudarshan, Nwabor, Ozioma Forstinus, Chusri, Sarunyou, Kaewnam, Wijittra, Kanokwiroon, Kanyanatt, Septama, Abdi Wira, Panichayupakaranant, Pharkphoom, Voravuthikunchai, Supayang Piyawan
Format: Article
Language:English
Subjects:
Anti-inflammatory
Anti-inflammatory agents
Anti-oxidant
Antibacterial
Antibiotics
Antiinfectives and antibacterials
Antioxidants
Biochemical analysis
Biocompatibility
Biological activity
Biological properties
Biomedicine
Cell viability
Chromatography
Gas chromatography
Inflammation
Interleukin 6
Leaves
Lipopolysaccharides
Macrophages
Mass spectrometry
Mass spectroscopy
mRNA
Nitric oxide
Nitric-oxide synthase
Phytosterols
Rhodomyrtone
Rhodomyrtus tomentosa
Safety
Sesquiterpenes
Topical application
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Summary:Series of works on the biological properties of rhodomyrtone, a major active component of Rhodomyrtus tomentosa leaf has been reported. In this study, rhodomyrtone-rich microwave-assisted extract from R. tomentosa leaf (RT-MAE) before formulation was profiled for phytochemical composition using gas chromatography-mass spectrometry (GC-MS) and targeted for anti-inflammatory activity with topical application. The formulation was assessed for bioactivity, biocompatibility, and safety on human volunteers. The GC-MS spectra indicated a rich content of phytosterols, sesquiterpenes, and acylphloroglucinols. At concentrations 50-600 ng/mL, RT-MAE before formulation treated macrophages showed >86% cell viability. Nitric oxide production significantly decreased by 19.26-88.36% following the treatment with 50-600 ng/mL RT-MAE before formulation (p 
ISSN:0149-6395
1520-5754
DOI:10.1080/01496395.2023.2169162