Xanthones from the latex and twig extracts of Garcinia nigrolineata Planch. ex T. Anderson (Clusiaceae) and their antidiabetic and cytotoxic activities

A new geranylated xanthone, nigrolineaxanthone AA (1) together with 18 known compounds (2-19) were isolated from latex and twig extracts of Garcinia nigrolineata Planch. ex T. Anderson. Some of the isolated compounds were assessed for their antidiabetic activities and cytotoxicity against three canc...

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Bibliographic Details
Published in:Natural product research 2023-03, Vol.37 (5), p.702-712
Main Authors: Phukhatmuen, Piyaporn, Suthiphasilp, Virayu, Rujanapan, Narawadee, Duangyod, Thidarat, Maneerat, Tharakorn, Charoensup, Rawiwan, Laphookhieo, Surat
Format: Article
Language:English
Subjects:
antidiabetic activity
Antineoplastic Agents
Clusiaceae
Colon cancer
cytotoxic activity
Cytotoxicity
Diabetes mellitus
Garcinia
Garcinia nigrolineata
Glucose
Glucosidase
Glycosylation
Hypoglycemic Agents - pharmacology
Latex
Leukemia
Molecular Structure
Plant Extracts - pharmacology
Toxicity
Tumor cell lines
xanthone
Xanthones - pharmacology
α-Amylase
α-Glucosidase
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Summary:A new geranylated xanthone, nigrolineaxanthone AA (1) together with 18 known compounds (2-19) were isolated from latex and twig extracts of Garcinia nigrolineata Planch. ex T. Anderson. Some of the isolated compounds were assessed for their antidiabetic activities and cytotoxicity against three cancer cell lines. Of these, compounds 12 (IC 50 value of 25.8 ± 0.2 µM), 16 (IC 50 value of 124.8 ± 0.7 µM), and 17 (IC 50 value of 44.4 ± 1.1 µM) exhibited the highest α-glucosidase inhibitory, α-amylase inhibitory, and glycation inhibition activities, respectively. Compound 11 showed glucose consumption and glucose uptake with IC 50 values of 14.2 ± 0.8 µM and 3.1-fold. Compound 10 displayed cytotoxic activity against colon cancer (SW480) with an IC 50 value of 4.3 ± 0.1 µM), while compound 2 showed cytotoxicity against leukemic cancer (K562) with IC 50 value of 4.4 ± 0.3 µM.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2086544