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Morphologic and molecular biologic analyses of the skin rejuvenation effect of the fractional 1064‐nm picosecond laser: An animal study

Objectives Application of the picosecond laser in the field of dermatology has expanded from tattoo removal to skin rejuvenation on a clinical basis. Although various mechanisms of pigment removal have been elucidated, the molecular changes associated with skin rejuvenation have yet to be identified...

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Published in:Lasers in surgery and medicine 2023-02, Vol.55 (2), p.190-199
Main Authors: Lim, Sung Ha, Seo, Hee Seok, Lee, Young Bin, Kang, Hyun, Hong, Seung Phil
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Language:English
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creator Lim, Sung Ha
Seo, Hee Seok
Lee, Young Bin
Kang, Hyun
Hong, Seung Phil
description Objectives Application of the picosecond laser in the field of dermatology has expanded from tattoo removal to skin rejuvenation on a clinical basis. Although various mechanisms of pigment removal have been elucidated, the molecular changes associated with skin rejuvenation have yet to be identified. The aim of this study was to explore the theoretical basis and to evaluate the efficacy of skin rejuvenation using a 1064‐nm fractional picosecond laser in a mouse model. Methods We conducted an in vivo study using a fractional picosecond laser on the skin of old and young female hairless mice and performed topographical, histological, micro‐, and electron microscopic assessments. Results The topography of the skin surface was enhanced and showed increased dermal thickness on histological examination. Electron microscopy revealed disarranged collagen bundles with microspaces and vascular leakage in the upper dermis. Levels of collagen synthesis markers and various inflammatory cytokines, such as procollagens, interleukin‐1β, tumor necrosis factor‐α, and heat shock proteins, were elevated in the laser‐treated skin. Conclusions This study provides a possible mechanism for the skin rejuvenation effect of fractional picosecond laser that has been reported previously in clinical observations. Based on our findings, the fractional picosecond laser could be widely applied in clinical settings where dermal regeneration and promotion of skin rejuvenation is required.
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Although various mechanisms of pigment removal have been elucidated, the molecular changes associated with skin rejuvenation have yet to be identified. The aim of this study was to explore the theoretical basis and to evaluate the efficacy of skin rejuvenation using a 1064‐nm fractional picosecond laser in a mouse model. Methods We conducted an in vivo study using a fractional picosecond laser on the skin of old and young female hairless mice and performed topographical, histological, micro‐, and electron microscopic assessments. Results The topography of the skin surface was enhanced and showed increased dermal thickness on histological examination. Electron microscopy revealed disarranged collagen bundles with microspaces and vascular leakage in the upper dermis. Levels of collagen synthesis markers and various inflammatory cytokines, such as procollagens, interleukin‐1β, tumor necrosis factor‐α, and heat shock proteins, were elevated in the laser‐treated skin. Conclusions This study provides a possible mechanism for the skin rejuvenation effect of fractional picosecond laser that has been reported previously in clinical observations. Based on our findings, the fractional picosecond laser could be widely applied in clinical settings where dermal regeneration and promotion of skin rejuvenation is required.</description><identifier>ISSN: 0196-8092</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/lsm.23623</identifier><identifier>PMID: 36573446</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>animal study ; Animals ; Biological Products - metabolism ; Collagen ; Collagen - metabolism ; Dermatology ; Dermis ; Electron microscopy ; Female ; Hairless ; Heat shock factors ; Heat shock proteins ; In vivo methods and tests ; Inflammation ; Interleukins ; Lasers ; Lasers, Solid-State - therapeutic use ; Mice ; molecular analysis ; morphologic analysis ; Nd:YAG picosecond laser ; Rejuvenation ; Skin ; Skin - pathology ; Skin Aging ; skin rejuvenation</subject><ispartof>Lasers in surgery and medicine, 2023-02, Vol.55 (2), p.190-199</ispartof><rights>2022 Wiley Periodicals LLC.</rights><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2803-276fdbbe59b44a0fdab6d7904f6f4fad4e9dbfe976eb7090cc36754af3215a373</cites><orcidid>0000-0002-2081-5261</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36573446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Sung Ha</creatorcontrib><creatorcontrib>Seo, Hee Seok</creatorcontrib><creatorcontrib>Lee, Young Bin</creatorcontrib><creatorcontrib>Kang, Hyun</creatorcontrib><creatorcontrib>Hong, Seung Phil</creatorcontrib><title>Morphologic and molecular biologic analyses of the skin rejuvenation effect of the fractional 1064‐nm picosecond laser: An animal study</title><title>Lasers in surgery and medicine</title><addtitle>Lasers Surg Med</addtitle><description>Objectives Application of the picosecond laser in the field of dermatology has expanded from tattoo removal to skin rejuvenation on a clinical basis. Although various mechanisms of pigment removal have been elucidated, the molecular changes associated with skin rejuvenation have yet to be identified. The aim of this study was to explore the theoretical basis and to evaluate the efficacy of skin rejuvenation using a 1064‐nm fractional picosecond laser in a mouse model. Methods We conducted an in vivo study using a fractional picosecond laser on the skin of old and young female hairless mice and performed topographical, histological, micro‐, and electron microscopic assessments. Results The topography of the skin surface was enhanced and showed increased dermal thickness on histological examination. Electron microscopy revealed disarranged collagen bundles with microspaces and vascular leakage in the upper dermis. Levels of collagen synthesis markers and various inflammatory cytokines, such as procollagens, interleukin‐1β, tumor necrosis factor‐α, and heat shock proteins, were elevated in the laser‐treated skin. 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Based on our findings, the fractional picosecond laser could be widely applied in clinical settings where dermal regeneration and promotion of skin rejuvenation is required.</description><subject>animal study</subject><subject>Animals</subject><subject>Biological Products - metabolism</subject><subject>Collagen</subject><subject>Collagen - metabolism</subject><subject>Dermatology</subject><subject>Dermis</subject><subject>Electron microscopy</subject><subject>Female</subject><subject>Hairless</subject><subject>Heat shock factors</subject><subject>Heat shock proteins</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Interleukins</subject><subject>Lasers</subject><subject>Lasers, Solid-State - therapeutic use</subject><subject>Mice</subject><subject>molecular analysis</subject><subject>morphologic analysis</subject><subject>Nd:YAG picosecond laser</subject><subject>Rejuvenation</subject><subject>Skin</subject><subject>Skin - pathology</subject><subject>Skin Aging</subject><subject>skin rejuvenation</subject><issn>0196-8092</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kD1PHDEQhq0oKBwkRf4AspSKYmH8cfZtuhPiI9IhCki98nrHYS_e9WHvgq6jpeM38kswuYMu1YxmHj0zegn5zuCIAfBjn7ojLhQXn8iEQamKkgH7TCbAcj-Dku-SvZSWACA46C9kV6ipFlKqCXm6DHF1G3z401pq-oZ2waMdvYm0bj_Gxq8TJhocHW6Rpr9tTyMux3vszdCGnqJzaIf3vYvGvo2NpwyUfHl87ju6am1IaEM-4U3C-JPO-2xuu0ylYWzWX8mOMz7ht23dJ7_PTm9OLorF1fmvk_misHwGouBauaaucVrWUhpwjalVo0uQTjnpTCOxbGqHpVZYayjBWqH0VBonOJsaocU--bHxrmK4GzEN1TKMMT-bKq61lnLG2SxThxvKxpBSRFetYv41risG1VvoVQ69-hd6Zg-2xrHusPkg31POwPEGeGg9rv9vqhbXlxvlK2FQjpE</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Lim, Sung Ha</creator><creator>Seo, Hee Seok</creator><creator>Lee, Young Bin</creator><creator>Kang, Hyun</creator><creator>Hong, Seung Phil</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-2081-5261</orcidid></search><sort><creationdate>202302</creationdate><title>Morphologic and molecular biologic analyses of the skin rejuvenation effect of the fractional 1064‐nm picosecond laser: An animal study</title><author>Lim, Sung Ha ; 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subjects animal study
Animals
Biological Products - metabolism
Collagen
Collagen - metabolism
Dermatology
Dermis
Electron microscopy
Female
Hairless
Heat shock factors
Heat shock proteins
In vivo methods and tests
Inflammation
Interleukins
Lasers
Lasers, Solid-State - therapeutic use
Mice
molecular analysis
morphologic analysis
Nd:YAG picosecond laser
Rejuvenation
Skin
Skin - pathology
Skin Aging
skin rejuvenation
title Morphologic and molecular biologic analyses of the skin rejuvenation effect of the fractional 1064‐nm picosecond laser: An animal study
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