Characteristics of Resting State Functional Connectivity of the Brain in Patients with Lateralized Damage to the Mediobasal Areas of the Temporal Lobe (fMRI and EEG data)

• Published in: Neuroscience and behavioral physiology 2022-10, Vol.52 (8), p.1237-1246
• Main Authors: Kuleva, A. Yu, Sharova, E. V., Boldyreva, G. N., Strunina, Yu.V., Yarets, M. Yu, Galkin, M. V., Bychkova, A. S., Smirnov, A. S., Krotkova, O. A.
• Format: Article
• Language: English
• Subjects: Behavioral Sciences; Biomedical and Life Sciences; Biomedicine; Brain mapping; EEG; Executive function; Functional magnetic resonance imaging; Hemispheric laterality; Measuring techniques; Memory; Neural networks; Neurobiology; Neuropsychology; Neurosciences; Psychology; Structure-function relationships; Temporal cortex; Temporal lobe; Topography; Tumors
• ISSN: 0097-0549; 1573-899X
• DOI: 10.1007/s11055-023-01352-5

Structural and functional support of executive functions, currently under active investigation, is largely associated with the prefrontal and parietal parts of the hemispheres. The aim of the present work was to clarify the involvement of the medial parts of the temporal lobe in forming executive functions. The study involved14 patients with extracerebral tumors (meningiomas) with compressive actions on the mediobasal parts of the temporal lobe of the corresponding hemisphere. Tumors were located on the right side in seven cases and on the left in the other seven. The control group consisted of nine healthy subjects. Resting fMRI was performed in the patients and healthy volunteers, with further analysis of functional connectivity between regions of interest (ROI) corresponding to the topography of the executive functions (EF) network. This was followed on the same day by recording of the multichannel EEG at rest with the eyes closed, with spectral coherence analysis of all possible combinations of lead pairs in the frequency bands of the main physiological rhythms. Additionally, neuropsychological testing was carried out using the method of visual memorization in the Eyetracker–Attention–Memory (EAM) method and the Stream of Consciousness Questionnaire during resting fMRI [ReSQ]. Analysis of fMRI and EEG connectivity at rest in patients as compared with healthy people revealed patterns of disturbances in functional connections which were similar for the two methods, with topography corresponding to that of the executive functions network, confirming the concept that the inferior temporal cortex is part of this system. The specific features of changes in connectivity in groups of patients with different lesion lateralization were established and were found to be consistent with neuropsychological test data and predominant in tumors located on the left side.