Synthesis and biological activity of iron(II), iron(III), nickel(II), copper(II) and zinc(II) complexes of aliphatic hydroxamic acids

Aliphatic hydroxamic acids (HA) with varying numbers of carbon atoms, C 2 , C 6 , C 8 , C 10 , C 12 and C 17 , and corresponding Fe(II), Fe(III), Ni(II), Cu(II) and Zn(II) complexes have been synthesized and characterized by various methods, including structural determination by single crystal X-ray...

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Bibliographic Details
Published in:Journal of coordination chemistry 2023-01, Vol.76 (1), p.76-105
Main Authors: Sow, Ibrahima Sory, Gelbcke, Michel, Meyer, Franck, Vandeput, Marie, Marloye, Mickael, Basov, Sergey, Van Bael, Margriet J., Berger, Gilles, Robeyns, Koen, Hermans, Sophie, Yang, Dong, Fontaine, Véronique, Dufrasne, François
Format: Article
Language:English
Subjects:
Aliphatic compounds
antibacterial
antifungal
Biological activity
Coordination compounds
Copper
Fungicides
Hydroxamic acids
Iron
lipophilicity
metal complexes
Microorganisms
Nickel
Selectivity
Single crystals
Zinc compounds
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Summary:Aliphatic hydroxamic acids (HA) with varying numbers of carbon atoms, C 2 , C 6 , C 8 , C 10 , C 12 and C 17 , and corresponding Fe(II), Fe(III), Ni(II), Cu(II) and Zn(II) complexes have been synthesized and characterized by various methods, including structural determination by single crystal X-ray diffraction and theoretical calculations. The biological activities of HA and their complexes have been assessed on a panel of pathogens, including eight bacteria strains and one fungus. The C 12 aliphatic HA displayed the lowest minimum inhibitory concentrations (MIC) towards several microbial strains and a selective antifungal activity. This antifungal selectivity was further improved considering the Ni(II), Cu(II) and Zn(II) complexes of C 12 HA showed higher IC 50 values, thus less impact on the SiHa human cell line viability. This work warrants further investigation to understand the underlying mechanism of action and potential biological applications of HA and the derived metal complexes.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2023.2166407