Anti-neoplastic Effects of Gold Nanoparticles Synthesized Using Green Sources on Cervical and Melanoma Cancer Cell Lines

The cytotoxic and anti-proliferative effects of gold nanoparticles synthesized from green sources on cervical (HeLa) and melanoma (A375) cancer cells have been studied. These nanoparticles were synthesized using sodium citrate, tannic acid, lemongrass extract, and green tea extract to compare the ef...

Full description

Saved in:
Bibliographic Details
Published in:BioNanoScience 2023-03, Vol.13 (1), p.194-202
Main Authors: Dickson, Jared, Weaver, Brooke, Vivekanand, Pavithra, Basu, Swarna
Format: Article
Language:English
Subjects:
Antiproliferatives
Apoptosis
Biological and Medical Physics
Biomaterials
Biophysics
Cancer
Cell proliferation
Cell viability
Circuits and Systems
Cytotoxicity
Engineering
Fourier transforms
Gold
Green tea
Infrared analysis
Infrared spectroscopy
Melanoma
Nanoparticles
Nanotechnology
Plant extracts
Reducing agents
Ribose
Scanning electron microscopy
Sodium citrate
Synthesis
Tannic acid
Toxicity
Tumor cell lines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The cytotoxic and anti-proliferative effects of gold nanoparticles synthesized from green sources on cervical (HeLa) and melanoma (A375) cancer cells have been studied. These nanoparticles were synthesized using sodium citrate, tannic acid, lemongrass extract, and green tea extract to compare the effects of different reducing agents on the ability to affect cancer cell viability. The nanoparticles were characterized using absorption and Fourier-transform infrared (FT-IR) spectroscopy, particle-size analysis, and scanning electron microscopy (SEM). Cancer cells were treated with gold nanoparticles at concentrations ranging from 25 to 100 μg/mL for 48 h and revealed dose-dependent cytotoxicity. The effects on cell viability were mediated by induction of apoptosis, as poly (ADP-ribose) polymerase (PARP) cleavage was observed in HeLa and A375 cells treated with tannic acid gold nanoparticles and in HeLa cells treated with green tea gold nanoparticles. Additionally, cell proliferation assays revealed decreased proliferation of A375 cells treated with green synthesized, but not traditional gold nanoparticles. Collectively, these results suggest that gold nanoparticles synthesized using plant extracts have a promising potential as a cancer treatment method as they exhibit both pro-apoptotic and anti-proliferative effects towards multiple cancer cell lines.
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-022-01056-z