The Combined Effect of Protective Agents and Accelerated Carbon Ions on the Behavior of Mice

The combined effect of protective agents (helium-neon laser, ibuprofen, mexidol) and 3 Gy of accelerated carbon ions ( 12 C) on the cognitive abilities of mice was studied. It was shown that the irradiated animals did not exhibit an altered behavior pattern: the level of anxiety was not increased, t...

Full description

Saved in:
Bibliographic Details
Published in:Biology bulletin of the Russian Academy of Sciences 2022-12, Vol.49 (12), p.2303-2308
Main Authors: Sorokina, S. S., Paskevich, S. I., Zaichkina, S. I., Malkov, A. E., Pikalov, V. A.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Carbon
Cell Biology
Cognitive ability
Ecology
Helium
Hippocampus
Life Sciences
Memory
Modification of Radiation Effects
Motor skill learning
Short term memory
Zoology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The combined effect of protective agents (helium-neon laser, ibuprofen, mexidol) and 3 Gy of accelerated carbon ions ( 12 C) on the cognitive abilities of mice was studied. It was shown that the irradiated animals did not exhibit an altered behavior pattern: the level of anxiety was not increased, there was a slower positive dynamics of learning compared to the control, and there was no deficit in the hippocampus-dependent memory. Analysis of variance of learning curves revealed different coefficients of skill acquisition within the experimental groups, with the lowest characteristic for the group irradiated with a dose of 3 Gy 12 C without protective agents. In addition, the analysis of the preference for novelty when testing for recognition of a new object showed that this group of animals has a violation of the nonspatial hippocampus-mediated short-term memory.
ISSN:1062-3590
1608-3059
DOI:10.1134/S1062359022120226