Influence of Bisphenol A and 17β‐Trenbolone Exposure in Oryzias Congeners

Japanese medaka is specified as a model fish in the test guidelines of the Organisation for Economic Co‐operation and Development. Recently, populations of Japanese medaka in Japan were divided into two species, the northern Oryzias sakaizumii and the southern O. latipes. Previously, we reported tha...

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Bibliographic Details
Published in:Environmental toxicology and chemistry 2023-03, Vol.42 (3), p.673-678
Main Authors: Horie, Yoshifumi, Chiba, Takashi
Format: Article
Language:English
Subjects:
Animals
Bisphenol A
Congeners
Disruption
Economic models
Endocrine disruptors
endocrine‐disrupting chemicals
Exposure
Female
Gonads
gsdf
histology
Male
medaka
Methyltestosterone
Oryzias - metabolism
Oryzias latipes
Sex
Sex differentiation
Sex reversal
Testis - metabolism
testis–ova
toxic effects
Trenbolone
Trenbolone Acetate
Xenoestrogens
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Summary:Japanese medaka is specified as a model fish in the test guidelines of the Organisation for Economic Co‐operation and Development. Recently, populations of Japanese medaka in Japan were divided into two species, the northern Oryzias sakaizumii and the southern O. latipes. Previously, we reported that induction concentrations for sex reversal by exposure to 17α‐methyltestosterone differed significantly between these two species, indicating that they respond differently to endocrine‐disrupting chemica. In the present study, we examined the effects of exposure to two more endocrine‐disrupting chemicals (bisphenol A and 17β‐trenbolone) in O. sakaizumii, and compared the results with those previously reported for O. latipes. Exposure to both bisphenol A and 17β‐trenbolone induced testis–ova formation or sex reversal in O. sakaizumii. Exposure to 17β‐trenbolone also increased expression of gonadal soma‐derived factor (gsdf). Least‐observed‐effect concentrations for gonadal sex differentiation and gsdf expression were lower for O. latipes than for O. sakaizumii after exposure to bisphenol A, and were lower for O. sakaizumii than for O. latipes after exposure to 17β‐trenbolone. These results demonstrate that O. sakaizumii and O. latipes respond differently to androgenic and estrogenic endocrine‐disrupting chemicals. Environ Toxicol Chem 2023;42:673–678. © 2022 SETAC
ISSN:0730-7268
1552-8618
DOI:10.1002/etc.5552