543 EEG-Based Deep Neural Network Model for Brain Age Prediction and Its Association with Patient Health Conditions

Introduction Electroencephalogram (EEG) provides clinically relevant information for personalized patient health evaluation and comprehensive assessment of sleep. EEG-based indices have been associated with neurodegenerative conditions, psychiatric disorders, and metabolic and cardiovascular disease...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 2021-05, Vol.44 (Supplement_2), p.A214-A214
Main Authors: Nygate, Yoav, Rusk, Sam, Fernandez, Chris, Glattard, Nick, Arguelles, Jessica, Shi, Jiaxiao, Hwang, Dennis, Watson, Nathaniel
Format: Article
Language:English
Subjects:
Age
Biomarkers
Diabetes
Electroencephalography
Neural networks
Patients
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Summary:Introduction Electroencephalogram (EEG) provides clinically relevant information for personalized patient health evaluation and comprehensive assessment of sleep. EEG-based indices have been associated with neurodegenerative conditions, psychiatric disorders, and metabolic and cardiovascular disease, and hold promise as a biomarker for brain health. Methods A deep neural network (DNN) model was trained to predict the age of patients using raw EEG signals recorded during clinical polysomnography (PSG). The DNN was trained on N=126,241 PSGs, validated on N=6,638, and tested on a holdout set of N=1,172. The holdout dataset included several categories of patient demographic and diagnostic parameters, allowing us to examine the association between brain age and a variety of medical conditions. Brain age was assessed by subtracting the individual’s chronological brain age from their EEG-predicted brain age (Brain Age Index; BAI), and then taking the absolute value of this variable (Absolute Brain Age Index; ABAI). We then constructed two regression models to test the relationship between BAI/ABAI and the following list of patient parameters: sex, BMI, depression, alcohol/drug problems, memory/concentration problems, epilepsy/seizures, diabetes, stroke, severe excessive daytime sleepiness (e.g., Epworth Sleepiness Scale ≥ 16; EDS), apnea-hypopnea index (AHI), arousal index (ArI), and sleep efficiency (SE). Results The DNN brain age model produced a mean absolute error of 4.604 and a Pearson’s r value of 0.933 which surpass the performance of prior research. In our regression analyses, we found a statistically significant relationship between the ABAI and: epilepsy and seizure disorders, stroke, elevated AHI, elevated ArI, and low SE (all p
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/zsab072.541