Catalyst-free visible-light-induced decarbonylative C–H alkylation of quinoxalin-2(1H)-ones

Direct functionalization of C(sp3)–H bonds is an effective, straightforward method for accessing a diverse array of heteroarene derivatives. However, its wide application is limited by the need for the use of catalysts or oxidants. In this study, we developed a mild, eco-friendly, practical photoche...

Full description

Saved in:
Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2023-02, Vol.10 (5), p.1296-1300
Main Authors: Shi, Xiaodi, Cao, Yunpeng, Liu, Yuxiu, Niu, Kaikai, Song, Hongjian, Zhang, Jingjing, Wang, Qingmin
Format: Article
Language:English
Subjects:
Air temperature
Aldehydes
Alkylation
Catalysts
Light effects
Organic chemistry
Oxidants
Oxidizing agents
Photochemicals
Room temperature
Substrates
Temperature tolerance
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Direct functionalization of C(sp3)–H bonds is an effective, straightforward method for accessing a diverse array of heteroarene derivatives. However, its wide application is limited by the need for the use of catalysts or oxidants. In this study, we developed a mild, eco-friendly, practical photochemical protocol for decarbonylative C–H alkylation reactions of quinoxalin-2(1H)-ones and aliphatic aldehydes with air as the oxidant at room temperature. These catalyst- and oxidant-free reactions showed good functional-group tolerance and a broad substrate scope.
ISSN:2052-4110
2052-4110
DOI:10.1039/d2qo02019j