Synthesis of purine conjugates with N-(4-aminobenzenesulfonyl)-and N-(2-aminoethanesulfonyl)-(S)-glutamic acids

The approaches to the synthesis of purine conjugates with N -(4-aminobenzenesulfonyl)-( S )-glutamic acid and N -(2-ammoethanesulfonyl)-( S )-glutamic acid by nucleophilic substitution of chlorine atom in 6-chloropurine derivatives have been developed. The studied compounds did not show significant...

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Bibliographic Details
Published in:Russian chemical bulletin 2022-12, Vol.71 (12), p.2685-2690
Main Authors: Vigorov, A. Yu, Gorbunov, E. B., Ezhikova, M. A., Kodess, M. I., Belyaev, D. V., Vakhrusheva, D. V., Levit, G. L., Krasnov, V. P.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chlorine compounds
Conjugates
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Glutamic acid
Inorganic Chemistry
Organic Chemistry
Synthesis
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Summary:The approaches to the synthesis of purine conjugates with N -(4-aminobenzenesulfonyl)-( S )-glutamic acid and N -(2-ammoethanesulfonyl)-( S )-glutamic acid by nucleophilic substitution of chlorine atom in 6-chloropurine derivatives have been developed. The studied compounds did not show significant antimycobacterial activity in the in vitro experiment.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-022-3697-6