Influence of vitamin E on the cellular uptake and transport of selenium from wheat and pearl millet across Caco-2 cell monolayer

The purpose of the current study was to evaluate the effect of exogenous addition of vitamin E on the cellular uptake and transport of selenium (Se) across Caco-2 cell monolayer from wheat and pearl millet. Cellular bioavailability of Se was also determined by evaluating the activity of Se dependent...

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Bibliographic Details
Published in:Journal of food measurement & characterization 2023-04, Vol.17 (2), p.1480-1491
Main Authors: Khanam, Anjum, Kizhakayil, Dhanya, Platel, Kalpana
Format: Article
Language:English
Subjects:
Amino acids
Antibiotics
Bioavailability
Cancer
Cell culture
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Engineering
Enzymes
Food
Food Science
Gene expression
Glutathione
Glutathione peroxidase
Millet
Monolayers
Original Paper
Pennisetum glaucum
Peroxidase
Reductases
Selenium
Selenocysteine
Selenomethionine
Thioredoxin
Tocopherol
Vitamin E
Wheat
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Summary:The purpose of the current study was to evaluate the effect of exogenous addition of vitamin E on the cellular uptake and transport of selenium (Se) across Caco-2 cell monolayer from wheat and pearl millet. Cellular bioavailability of Se was also determined by evaluating the activity of Se dependent enzymes such as glutathione peroxidase (GPx) and thioredoxin reductase (TR). Transport and uptake of Se was by passive diffusion (transcellular transport), which was time dependent. Uptake of selenomethionine (SeMet) and selenocysteine (SeCys 2 ) by the Caco-2 cells incubated with wheat and pearl millet was significantly enhanced (p 
ISSN:2193-4126
2193-4134
DOI:10.1007/s11694-022-01689-4