Recent updates on thienopyrimidine derivatives as anticancer agents

Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds. They are important and widely represented in medicinal chemistry as they are structural analogs of purines. Thienopyrimidine derivatives have various biological activities. The current review discusses different syn...

Full description

Saved in:
Bibliographic Details
Published in:Medicinal chemistry research 2023-04, Vol.32 (4), p.659-681
Main Authors: Sayed, Menna Tallah M., Hassan, Rasha A., Halim, Peter A., El-Ansary, Afaf K.
Format: Article
Language:English
Subjects:
Anticancer properties
Antitumor agents
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Inorganic Chemistry
Medicinal Chemistry
Pharmacology/Toxicology
Purines
Review Article
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds. They are important and widely represented in medicinal chemistry as they are structural analogs of purines. Thienopyrimidine derivatives have various biological activities. The current review discusses different synthetic methods for the preparation of heterocyclic thienopyrimidine derivatives. It also highlights the most recent research on the anticancer effects of thienopyrimidines through the inhibition of various enzymes and pathways, which was published within the last 9 years. Graphical Abstract
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-023-03040-y