Cobalt‐Catalyzed Cascade Reaction of Ynamides and 1,3‐Dicarbonyl Compounds for Selective Synthesis of Differently Sized N‐Heterocycles

A triphenylphosphine‐ligated cobalt‐catalyzed cyclization manifold with various 1,3‐dicarbonyl compounds and halogenated N‐allyl ynamides was accomplished under alkaline reaction conditions, facilitating the synthesis of differently sized N‐heterocycles. A large array of products was prepared to dem...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2023-03, Vol.365 (5), p.753-759
Main Authors: Zhang, Biao, Yang, Xu‐Heng, Huang, Jian, Tao, Cheng‐an, Wang, Jianfang
Format: Article
Language:English
Subjects:
1,3-dicarbonyl compounds
azepines
Carbonyl compounds
Cascade chemical reactions
cascade reaction
Chemical synthesis
cobalt catalysis
Cobalt compounds
cyclization
Functional groups
Substrates
ynamides
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Summary:A triphenylphosphine‐ligated cobalt‐catalyzed cyclization manifold with various 1,3‐dicarbonyl compounds and halogenated N‐allyl ynamides was accomplished under alkaline reaction conditions, facilitating the synthesis of differently sized N‐heterocycles. A large array of products was prepared to demonstrate the selective synthesis of N‐heterocycles of different ring sizes (5‐, 6‐, and 7‐membered rings) via cobalt catalysis. The reaction has broad substrate scope and a wide range of functional groups.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202201002