Synthesis and Antibacterial Activity of 4-Oxo-2-thienylaminobut-2-enoic Acids

The hydrolysis of substituted 3-(3-cyanothiophen-2-yl)imino-3 H -furan-2-ones was studied. It was found that the reaction proceeds with the opening of the furan ring and the formation of the corresponding 4-oxo-2-(3-cyanothiophen-2-yl)aminobut-2-enoic acids. The antibacterial activity of the obtaine...

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Bibliographic Details
Published in:Russian journal of general chemistry 2023, Vol.93 (1), p.8-15
Main Authors: Gorbunova, I. A., Shadrin, V. M., Pulina, N. A., Novikova, V. V., Dubrovina, S. S., Shipilovskikh, D. A., Shipilovskikh, S. A.
Format: Article
Language:English
Subjects:
Antibacterial agents
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
E coli
Escherichia coli
Furans
Hydrolysis
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Summary:The hydrolysis of substituted 3-(3-cyanothiophen-2-yl)imino-3 H -furan-2-ones was studied. It was found that the reaction proceeds with the opening of the furan ring and the formation of the corresponding 4-oxo-2-(3-cyanothiophen-2-yl)aminobut-2-enoic acids. The antibacterial activity of the obtained compounds against Staphylococcus aureus , Escherichia coli and Candida albicans was studied.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223010024