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Thermochemistry of fusion of benzocaine and S-naproxen between 298.15 K and Tm studied by solution and fast scanning calorimetry

Thermodynamic parameters of fusion define the solubility and stability of the crystalline materials and thus are important in the field of pharmaceutics. However, determining these parameters in practice by the common approaches, such as differential scanning calorimetry, is often hindered by the ev...

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Published in:Journal of thermal analysis and calorimetry 2023-03, Vol.148 (6), p.2457-2466
Main Authors: Yagofarov, Mikhail I., Sokolov, Andrey A., Ziganshin, Marat A., Mukhametzyanov, Timur A., Solomonov, Boris N.
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description Thermodynamic parameters of fusion define the solubility and stability of the crystalline materials and thus are important in the field of pharmaceutics. However, determining these parameters in practice by the common approaches, such as differential scanning calorimetry, is often hindered by the evaporation and degradation at high temperatures. Thus, the development of the independent approaches for determination of thermodynamic parameters of melting is important from both fundamental and practical standpoints. In this work two active pharmaceutical ingredients, S -naproxen and benzocaine, were studied by differential scanning calorimetry, fast scanning calorimetry, and solution calorimetry. Solution calorimetry was used to independently find the fusion enthalpies at 298.15 K. Fast scanning calorimetry was used to access the heat capacities of the supercooled liquid states. The literature data on the fusion enthalpies and heat capacities of the solid and liquid were collected and critically analyzed, considering the performed measurements. As a result, a consistent set of the fusion enthalpies and solid and liquid heat capacities between 298.15 K and melting point of S -naproxen and benzocaine was derived. The viability of the solution calorimetry approach was verified for polyfunctional organic molecules, providing a basis for the further use of this approach in the field of the thermochemistry of the pharmaceutically active compounds.
doi_str_mv 10.1007/s10973-022-11676-y
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subjects Analytical Chemistry
Chemistry
Chemistry and Materials Science
Differential scanning calorimetry
Enthalpy
Heat measurement
High temperature
Inorganic Chemistry
Measurement Science and Instrumentation
Melting points
Naproxen
Organic chemistry
Parameters
Physical Chemistry
Polymer Sciences
Specific heat
Thermochemistry
Thermodynamics
title Thermochemistry of fusion of benzocaine and S-naproxen between 298.15 K and Tm studied by solution and fast scanning calorimetry
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