Paper-based microfluidics in sweat detection: from design to application

Sweat, as a sample that includes a lot of biochemical information, is good for non-invasive monitoring. In recent years, there have been an increasing number of studies on in situ monitoring of sweat. However, there are still some challenges for the continuous analysis of samples. As a hydrophilic,...

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Bibliographic Details
Published in:Analyst (London) 2023-03, Vol.148 (6), p.1175-1188
Main Authors: Ye, Zhichao, Yuan, Yuyang, Zhan, Shaowei, Liu, Wei, Fang, Lu, Li, Tianyu
Format: Article
Language:English
Subjects:
Biosensing Techniques
Microfluidics
Monitoring
Substrates
Sweat
Sweat - chemistry
Wearable Electronic Devices
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Summary:Sweat, as a sample that includes a lot of biochemical information, is good for non-invasive monitoring. In recent years, there have been an increasing number of studies on in situ monitoring of sweat. However, there are still some challenges for the continuous analysis of samples. As a hydrophilic, easy-to-process, environmentally friendly, inexpensive and easily accessible material, paper is an ideal substrate material for making in situ sweat analysis microfluidics. This review introduces the development of paper as a sweat analysis microfluidic substrate material, focusing on the advantages of the structural characteristics of paper, trench design and equipment integration applications to expand the design and research ideas for the development of in situ sweat detection technology. Paper-based microfluidics offers a promising way to in situ sweat detection for non-invasive continuous monitoring. This passage reviews and prospects its development regarding materials, structuring, fabrication, modular design and application.
ISSN:0003-2654
1364-5528
DOI:10.1039/d2an01818g