Disulfiram Ethanol Reaction with Ischemic Stroke

Disulfiram (tetraethylthiuram disulfide) has been used since decades in the treatment of alcohol addiction. It causes aversive behaviour towards alcohol due to Disulfiram Ethanol Reaction (DER). The classical DER includes flushing, sweating, tremors, nausea, vomiting, tachycardia, hypotension and re...

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Bibliographic Details
Published in:Electronic journal of general medicine 2014-01, Vol.11 (3), p.190
Main Authors: Babu, M Suresh, Shetty, C.S.Chandrashekhar, Aiyappa, M.R., Sameer, Sasidharan
Format: Article
Language:English
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Summary:Disulfiram (tetraethylthiuram disulfide) has been used since decades in the treatment of alcohol addiction. It causes aversive behaviour towards alcohol due to Disulfiram Ethanol Reaction (DER). The classical DER includes flushing, sweating, tremors, nausea, vomiting, tachycardia, hypotension and restlessness. Complete recovery is the usual outcome in clinical settings. Life threatening reactions are rare but sometimes occur. Rare complications include shock, myocardial ischemia, hypertension, bronchospasm and methemoglobinemia. We present here a very rare case of ischemic stroke in a hemodynamically stable patient, which developed secondary to disulfiram–ethanol reaction. To the best of our knowledge, this is the first such reported case in literature.
ISSN:2516-3507
2516-3507
DOI:10.15197/sabad.1.11.68