Serum paraoxanase-1 activity in patients with acute otitis media

Objectives: Paraoxonase is a high-density lipoprotein (HDL)-associated antioxidant enzyme. We aimed to compare the activity of serum paraoxanase-1 (PON 1) in healthy controls and patients with acute otitis media (AOM). Subjects and methods: We performed a prospective controlled trial in patients wit...

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Bibliographic Details
Published in:Journal of clinical and experimental investigations 2011-12, Vol.2 (4), p.412
Main Authors: Koç, Sema, Duygu, Fazilet, Eyibilen, Ahmet, Aksoy, Nurten, Taskin, Abdullah, Bilinc, Hasan
Format: Article
Language:English
Subjects:
Ear diseases
Enzymes
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Summary:Objectives: Paraoxonase is a high-density lipoprotein (HDL)-associated antioxidant enzyme. We aimed to compare the activity of serum paraoxanase-1 (PON 1) in healthy controls and patients with acute otitis media (AOM). Subjects and methods: We performed a prospective controlled trial in patients with AOM. A total of 60 subjects, 30 patients with AOM (17 male; age, 15 ± 9 years) and 30 age- and sex-matched controls (16 male; age, 16 ± 5 years) were enrolled in this study. PON 1 activity was measured using Mackness’ methods. Results: PON 1 activity was significantly lower in the AOM group compared to control group (155 ± 95 U/L vs. 210 ± 96 U/L, P=0.04). Conclusions: The present study demostrates that serum PON 1 activity is low in AOM, similar to other conditions with increased oxidative stress. We speculate that PON 1 enzyme is consumed at a greater rate during AOM in order to prevent increased oxidative damage.
ISSN:1309-6621
1309-6621
DOI:10.5799/ahinjs.01.2011.04.0083