Analysis of length distribution of short DNA fragments induced by7Li ions using the random-breakage model

Deoxyribonucleic acid (DNA) is an important bio-macromolecule. DNA double strand breaks (DSBs) are considered to be the most important initial damage responsible for all biological effects induced by ionizing radiation. In this paper the length distribution of DNA fragments induced by 7Li ionizing r...

Full description

Saved in:
Bibliographic Details
Published in:Chinese science bulletin 2005-05, Vol.50 (9), p.841-844
Main Authors: Fuquan, Kong, Kui, Zhao, Yong, Zhan, Tianguang, Cao, Meinan, Ni, Li, Sui, Minghui, Cai, Yizhong, Zhuo
Format: Article
Language:English
Subjects:
Biological effects
Breakage
Deoxyribonucleic acid
DNA
DNA damage
Experimental data
Fragments
Ionizing radiation
Radiation damage
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Deoxyribonucleic acid (DNA) is an important bio-macromolecule. DNA double strand breaks (DSBs) are considered to be the most important initial damage responsible for all biological effects induced by ionizing radiation. In this paper the length distribution of DNA fragments induced by 7Li ionizing radiation is fitted with the random breakage model. In this model, the parameteru is the average number of DSBs on every DNA molecule induced by ionizing radiation. The fitting result shows that the random breakage model cannot describe the distribution of DNA fragments in lower doses, while the random breakage model is in better accordance with the experimental data in higher doses. It is shown that the length distribution of DNA fragments has random statistical feature in higher doses. In this situation, the random breakage model looks like a model without any parameter since theu has specific physical meaning and can directly be obtained from experimental data.
ISSN:1001-6538
2095-9273
1861-9541
2095-9281
DOI:10.1007/BF02897375