Ce⁴+-Stimulated Ion Fluxes Are Responsible for Apoptosis and Taxol Biosynthesis in Suspension Cultures of Taxus Cells

Ion fluxes across the plasma membrane activated by 1 mM Ce⁴+, cell apoptosis and taxol biosynthesis in suspension cultures of Taxus cuspidata were studied. The extracellular pH sharply decreased upon the addition of 1 mM Ce⁴+, then increased gradually and exceeded the initial pH value over a time pe...

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Bibliographic Details
Published in:Biotechnology and bioprocess engineering 2005-04, Vol.10 (2), p.109-114
Main Authors: Li, Jing-Chuan (Tianjin University, Tianjin, China), Ge, Zhi-Qiang (Tianjin University, Tianjin, China), Yuan, Ying-Jin (Tianjin University, Tianjin, China), E-mail: yjyuan@public.tpt.tj.cn
Format: Article
Language:English
Subjects:
APOPTOSE
APOPTOSIS
Biosynthesis
Calcium (extracellular)
Calcium influx
Calcium ions
Ce
Hydrogen
Ion channels
Ion flux
ion fluxes
Membranes
Necrosis
Paclitaxel
pH effects
Taxol
taxus cells
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Summary:Ion fluxes across the plasma membrane activated by 1 mM Ce⁴+, cell apoptosis and taxol biosynthesis in suspension cultures of Taxus cuspidata were studied. The extracellular pH sharply decreased upon the addition of 1 mM Ce⁴+, then increased gradually and exceeded the initial pH value over a time period of 12 h. The extracellular Ca²+ concentration decreased within the first 3 h after the addition of Ce⁴+, then gradually decreased to one third of initial value in control at about 72 h and remained unchanged afterwards.
ISSN:1226-8372
1976-3816
DOI:10.1007/BF02932579