Role of the diencephalic preoptic region in coordination of thermoregulatory and nutrition-related reactions

In acute experiments on cats we studied convergence of the afferent temperature-related and glycemic signals on the neurons of the preoptic region (RPO1). Local heating and cooling (±7°C) of the skin on the contralateral forelimb pad were used for identification ofRPO neurons as thermosensitive unit...

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Bibliographic Details
Published in:Neurophysiology (New York) 1998-11, Vol.30 (6), p.340-344
Main Authors: Kazakov, V. N., Kuznetsov, I. É.
Format: Article
Language:English
Subjects:
Convergence
Food consumption
Hypothalamus
Hypothalamus (lateral)
Localization
Neurons
Sensory neurons
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Summary:In acute experiments on cats we studied convergence of the afferent temperature-related and glycemic signals on the neurons of the preoptic region (RPO1). Local heating and cooling (±7°C) of the skin on the contralateral forelimb pad were used for identification ofRPO neurons as thermosensitive units, while infusion of 0.1–0.4 ml of 5.5% glucose solution in the ipsilaterala. carotis revealed their sensitivity to shifts in the glucose concentration. More than half (57%) of glucosensitiveRPO neurons responded to the changes in peripheral temperature. The pattern of convergence and peculiarities of localization of the convergent neurons were studied. We propose the following hypothesis:RPO neurons receiving convergent thermal and glycemic inputs provide formation of integral controlling signals addressed to the ventromedial and lateral hypothalamic nuclei, which control the thermoregulatory food consumption.
ISSN:0090-2977
1573-9007
DOI:10.1007/BF03027674