Electrical stimulation-based conductive hydrogel for immunoregulation, neuroregeneration and rapid angiogenesis in diabetic wound repair

Diabetic wounds are hard-healing chronic wounds, mainly caused by wound infection, excessive inflammation, diabetic neuropathy, and peripheral vascular disease. Hence, comprehensive improvement of diabetic wound healing is of great significance in clinical practice. However, the current research on...

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Bibliographic Details
Published in:Science China materials 2023-03, Vol.66 (3), p.1237-1248
Main Authors: Guan, Lin, Ou, Xiaolan, Wang, Ze, Li, Xingchen, Feng, Yubin, Yang, Xinting, Qu, Wenrui, Yang, Bai, Lin, Quan
Format: Article
Language:English
Subjects:
Angiogenesis
Chemistry and Materials Science
Chemistry/Food Science
Diabetes
Diabetic neuropathy
Electric fields
Hydrogels
Macrophages
Materials Science
Mechanical properties
Nanocrystals
Nanoparticles
Polypyrroles
Polyvinyl alcohol
Silver
Stimulation
Wound healing
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Summary:Diabetic wounds are hard-healing chronic wounds, mainly caused by wound infection, excessive inflammation, diabetic neuropathy, and peripheral vascular disease. Hence, comprehensive improvement of diabetic wound healing is of great significance in clinical practice. However, the current research on diabetic wounds mainly focuses on wound infection and angiogenesis, lacking the exploration of neuroregeneration and immunomodulation. In this study, we develop a multifunctional conductive hydrogel (PACPH) based on polydopamine-modified silver nanoparticles (AgNPs@PDA), cellulose nanocrystals (CNC)/polypyrrole (PPy) composites, and polyvinyl alcohol as an efficient wound dressing. The PACPH scaffold features multiple functions, including desirable mechanical properties, tissue adhesion, conductivity, and broad-spectrum antibacterial activity. Inspired by the endogenous electric field, the strategy of combining hydrogel with electrical stimulation (ES) is also proposed to accelerate the healing of diabetic wounds. Notably, the participation of ES can effectively promote nerve repair, realize the polarization of macrophages toward the M2 phenotype, and rapid angiogenesis, comprehensively improving the healing of diabetic wounds. This advanced collaborative strategy opens a new avenue in treating diabetic wounds.
ISSN:2095-8226
2199-4501
DOI:10.1007/s40843-022-2242-y