Usefulness of201Tl and99mTc MIBI scintigraphy in a case of oncogenic osteomalacia

A 45-year-old male was admitted with difficulty in walking due to leg pain. At the time of the first visit, a reduced serum phosphorus concentration and an increased serum alkaline phosphatase concentration of unknown etiology were observed. Either a whole body bone scintigraphy or CT of the neck, c...

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Bibliographic Details
Published in:Annals of nuclear medicine 2004-02, Vol.18 (1), p.63-67
Main Authors: Kimizuka, Takao, Ozaki, Yutaka, Sumi, Yukiharu
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Etiology
Osteomalacia
Phosphorus
Scintigraphy
Signs and symptoms
Single photon emission computed tomography
Sports injuries
Tumors
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Summary:A 45-year-old male was admitted with difficulty in walking due to leg pain. At the time of the first visit, a reduced serum phosphorus concentration and an increased serum alkaline phosphatase concentration of unknown etiology were observed. Either a whole body bone scintigraphy or CT of the neck, chest and abdominal region did not reveal any underlying disease. However both the whole body^sup 201^T1 scintigraphy and^sup 99m^Tc MIBI SPECT showed accumulation in the right knee region, and a small tumor was detected by MRI examination. After a diagnosis of oncogenic osteomalacia due to this tumor was determined the tumor was surgically removed, and turned out to be a hemangiopericytoma. By removal of the tumor, either the symptoms or the laboratory data were improved significantly. In this case, both^sup 201^T1 scintigraphy and^sup 99m^Tc scintigraphy MIBI were useful in identifying the location of the tumor which caused oncogenic osteomalacia.[PUBLICATION ABSTRACT]
ISSN:0914-7187
1864-6433
DOI:10.1007/BF02985616