111 A Novel Dual-Channel Deep Transcranial Magnetic Stimulator for Major Depressive Disorder

• Published in: CNS spectrums 2018-02, Vol.23 (1), p.71-72
• Main Authors: Harel, Eiran V, Shmuel, Dikla, Antler, Daniel, Katz, Dana, Pushkarski, Elina, Ais, Ezekiel, Schvartz, Anna, Tendler, Aron, Roth, Yiftach, Zangen, Abraham, Levkovitz, Yechiel
• Format: Article
• Language: English
• Subjects: Abstracts; Mental depression
• ISSN: 1092-8529; 2165-6509
• DOI: 10.1017/S1092852918000111

BackgroundRepetitive deep transcranial magnetic stimulation (dTMS) is efficacious for treatment resistant major depressive disorder (TRD) with the H1 coil by stimulating the prefrontal cortex, left more than right, at high frequency. Theoretically, the efficacy of dTMS could be optimized by simultaneously stimulating the right and left lateral prefrontal cortices (PFC) with different frequencies. This study tested the efficacy of a novel dual-channel dTMS stimulator with dual dTMS coils, in patients with TRD.MethodsThis study recruited forty-seven outpatients diagnosed with TRD, age 18-65, Hamilton Depression Rating Scale (HDRS-21) score ≥25. Each patient received 20 open label treatment sessions, five days a week for 4 consecutive weeks. Treatments were administered with the dual-channel stimulator (Brainsway Multiway dTMS device) using two channels: a. 10 Hz over the left PFC. b. 1 Hz over the right PFC. Primary and secondary efficacy outcome measures were the change in HDRS-21 score and response/remission rates at week 5, respectively.ResultsThe HDRS-21 score decreased from an average of 25.94 to 14.69 (P