Synthesis of pyrido[1,2- a ]indol-6(7 H )-ones via a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes

We successfully developed an unprecedented synthesis route to pyrido[1,2- a ]indol-6(7 H )-ones through a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes in a microchannel reactor. This novel protocol features extremely mild conditions, a b...

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Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2023-03, Vol.25 (6), p.2453-2457
Main Authors: Wei, Minghui, Liu, Chengkou, Wang, Chang-Sheng, Li, Yuguang, Qiu, Peng, Dong, Quanxiao, Yang, Zhao, Fang, Zheng, Guo, Kai
Format: Article
Language:English
Subjects:
Alkenes
Alkynes
Bromides
Cycloaddition
Green chemistry
Microchannels
Reaction mechanisms
Substrates
Synthesis
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Summary:We successfully developed an unprecedented synthesis route to pyrido[1,2- a ]indol-6(7 H )-ones through a visible light-photocatalyzed formal (4 + 2) cycloaddition of indole-derived bromides and alkenes or alkynes in a microchannel reactor. This novel protocol features extremely mild conditions, a broad substrate scope and high reaction efficiency. In addition, a reasonable reaction mechanism based on controlled experiments was proposed.
ISSN:1463-9262
1463-9270
DOI:10.1039/D2GC04491A