Non-invasive staging of liver fibrosis by two-dimensional shear wave elastography in patients with chronic hepatitis C and B

Background Non-invasive shear wave-based techniques have been developed for estimating liver fibrosis in patients with chronic liver diseases. Two-dimensional shear wave elastography provides in real-time, a tow dimensional quantitative map of tissue stiffness and enables measuring the stiffness by...

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Bibliographic Details
Published in:Egyptian journal of radiology and nuclear medicine 2021-05, Vol.52 (1), p.122-10
Main Authors: Alsowey, Ahmed M, Shehata, Samar M
Format: Article
Language:English
Subjects:
Ascites
Biopsy
Care and treatment
Development and progression
Enzymes
Fasting
Fibrosis
Fibrotest
Hepatitis B
Hepatitis C
Hepatitis C virus
Laboratories
Liver
Liver cirrhosis
Liver diseases
Liver fibrosis
Medical research
Medicine, Experimental
Patients
Propagation
Shear wave elastography
Software
Ultrasonic imaging
Veins & arteries
Velocity
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Summary:Background Non-invasive shear wave-based techniques have been developed for estimating liver fibrosis in patients with chronic liver diseases. Two-dimensional shear wave elastography provides in real-time, a tow dimensional quantitative map of tissue stiffness and enables measuring the stiffness by adjustment of a region of interest of tissue. The aim of this study was to highlight the role of tow dimensional shear wave elastography (2D-SWE) in detecting the degree of liver fibrosis in patients with chronic hepatitis C and B, in correlation with liver enzymes level and fibrotest. Results This study included 50 patients with chronic hepatitis C and B whose ages were (range, 30-65 years; mean, 48 years). Shear wave elastography cutoff values were 1.35 m/s, 5.48 KPa for (F>0); 1.66 m/s, 8.29 kPa for (F>1); 1.77 m/s, 9.40 kPa for (F>2); and 1.99 m/s, 11.9 kPa for (F>3). An excellent agreement was found between shear wave elastography and Fibrotest in staging of liver fibrosis in 88% of patients ([kappa].sub.w=0.943, 95% CI, 0.88 to 1.00) achieving a highly statistical significance (P
ISSN:0378-603X
2090-4762
DOI:10.1186/s43055-021-00502-4