Effects of pollutant toxicity on the eyes of aquatic life monitored by visual dysfunction in zebrafish: a review

The eyes of aquatic organisms may be damaged by exposure to pollutants. Zebrafish is a common laboratory model to study ocular toxicity, combining both fish and vertebrate characteristics. The toxic effects on zebrafish eyes caused by pollutants include morphological changes and damage to the retina...

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Bibliographic Details
Published in:Environmental chemistry letters 2023-04, Vol.21 (2), p.1177-1201
Main Authors: Chen, Xiao-Fan, Lin, Zhi-Cheng, Qi, Zenghua, Cai, Zongwei, Chen, Zhi-Feng
Format: Article
Language:English
Subjects:
Abnormalities
Analytical Chemistry
Aquatic life
Aquatic organisms
Behavior
Chemistry
Contaminants
Damage
Danio rerio
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Eye
Eye (anatomy)
Eye diseases
Fish
Freshwater fishes
Genes
Geochemistry
Glucose metabolism
Hormones
Laboratories
Malformations
Metabolism
Morphology
Phenotypes
Photoreceptors
Phototransduction
Pollutants
Pollution
Pollution effects
Pollution monitoring
Retina
Retinoic acid
ReviewPaper
Scale models
Signal transmission
Signaling
Thyroid
Toxicity
Vertebrates
Vision
Visual signals
Zebrafish
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Summary:The eyes of aquatic organisms may be damaged by exposure to pollutants. Zebrafish is a common laboratory model to study ocular toxicity, combining both fish and vertebrate characteristics. The toxic effects on zebrafish eyes caused by pollutants include morphological changes and damage to the retina at the molecular, cellular, and tissue levels; and abnormalities in the visual phototransduction and electrical signal transmission processes. Such damage induces functional disorders of vision-related behaviors. The underlying mechanisms include thyroid hormone signaling, retinoic acid signaling, and retinal glucose metabolism. Here, we review the ocular toxicity phenotypes and related signaling pathways induced by contaminants. We present detection methods and emerging tools for studying ocular toxicity. We also propose a model to predict the potential ocular toxicity of contaminants.
ISSN:1610-3653
1610-3661
DOI:10.1007/s10311-022-01531-9