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Apolipoprotein B level and diabetic microvascular complications: is there a correlation?
Introduction Dyslipidemia has long been implicated in diabetic complications. However, many subgroups have been considered to be responsible. Furthermore, a cause and effect relationship has long been debated. Apolipoprotein B (Apo B) is an exact measure of the total number of very low-density lipop...
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| Published in: | The Egyptian journal of internal medicine 2013-09, Vol.25 (3), p.137-142 |
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| creator | Rizk, Mary N. Aly, Hala Samir, Pierre Mofty, Hala el Allah, Osama K. |
| description | Introduction
Dyslipidemia has long been implicated in diabetic complications. However, many subgroups have been considered to be responsible. Furthermore, a cause and effect relationship has long been debated. Apolipoprotein B (Apo B) is an exact measure of the total number of very low-density lipoprotein and low-density lipoprotein particles; thus, total plasma Apo B is a reliable surrogate for actual low-density lipoprotein particle number irrespective of its size. Hence, it is a better indicator of the correlation between dyslipidemia and diabetic microvascular complications.
Aim of the work
Our aim is to study the correlation between Apo B and diabetic microvascular complications, namely, nephropathy and retinopathy.
Materials and methods
A cross sectional study was carried out of 56 diabetic patients, 36 men and 20 women, both type 1 and 2, who were chosen randomly from the outpatient Endocrinology Clinic in Cairo University. Serum creatinine, estimated glomerular filtration rate, urine albumin/ creatinine ratio (A/C ratio), and Apo B levels were determined. Groups were divided according to the A/C ratio as follows: no proteinuria (A/C ratio300mg/g). We performed fundus examination as well as fluorescein angiography in patients with retinopathy. Patients on dialysis, HBA1c more than 7.5, on lipid-lowering treatment, or with familial hyperlipidemia were excluded. Calculations were carried out using the SPSS v.10 statistical software.
Results
We found a significant positive correlation between Apo B levels and microvascular complications. Apo B was higher with overt nephropathy than incipient nephropathy (1.75 ±0.38), and higher in patients with incipient nephropathy (1.4± 0.48) than in patients without nephropathy (1.02 ± 0.34,
P |
| doi_str_mv | 10.7123/01.EJIM.0000432236.92356.43 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2790043903</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2790043903</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2443-b27ff6a50d29001a5f0a33262802dd53d4f06e9690113ea24e341e702e5acfa83</originalsourceid><addsrcrecordid>eNqNkE9Lw0AQxRdRsNR-h4WeE2f_JVkVpJaqlYoXBW_LNpnoSprE3bTgtzdphV6dyxzeezO8HyFTBnHKuLgEFi-els8x9CMF5yKJNRcqiaU4ISMOGiINOjslI8YYRGma8XMyCcGtQTHIlNIwIu-ztqlc27S-6dDV9I5WuMOK2rqghbNr7FxONy73zc6GfFtZT_Nm01Yut51r6nBFXaDdJ3qktle8x2ov3F6Qs9JWASd_e0ze7hev88do9fKwnM9WUc6lFNGap2WZWAUF1wDMqhKsEDzhGfCiUKKQJSSoEw2MCbRcopAMU-CobF7aTIzJ9HC3b_C9xdCZr2br6_6l4akeyGgQvev64OqLhOCxNK13G-t_DAMz0DTAzEDTHGmaPU0jh_TNIR36VP2B_vjjP_Ffv9l6Tg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2790043903</pqid></control><display><type>article</type><title>Apolipoprotein B level and diabetic microvascular complications: is there a correlation?</title><source>Springer Nature - SpringerLink Journals - Fully Open Access </source><source>Publicly Available Content (ProQuest)</source><creator>Rizk, Mary N. ; Aly, Hala ; Samir, Pierre ; Mofty, Hala el ; Allah, Osama K.</creator><creatorcontrib>Rizk, Mary N. ; Aly, Hala ; Samir, Pierre ; Mofty, Hala el ; Allah, Osama K.</creatorcontrib><description>Introduction
Dyslipidemia has long been implicated in diabetic complications. However, many subgroups have been considered to be responsible. Furthermore, a cause and effect relationship has long been debated. Apolipoprotein B (Apo B) is an exact measure of the total number of very low-density lipoprotein and low-density lipoprotein particles; thus, total plasma Apo B is a reliable surrogate for actual low-density lipoprotein particle number irrespective of its size. Hence, it is a better indicator of the correlation between dyslipidemia and diabetic microvascular complications.
Aim of the work
Our aim is to study the correlation between Apo B and diabetic microvascular complications, namely, nephropathy and retinopathy.
Materials and methods
A cross sectional study was carried out of 56 diabetic patients, 36 men and 20 women, both type 1 and 2, who were chosen randomly from the outpatient Endocrinology Clinic in Cairo University. Serum creatinine, estimated glomerular filtration rate, urine albumin/ creatinine ratio (A/C ratio), and Apo B levels were determined. Groups were divided according to the A/C ratio as follows: no proteinuria (A/C ratio<30mg/g), incipient proteinuria (30–300mg/g), and overt proteinuria (>300mg/g). We performed fundus examination as well as fluorescein angiography in patients with retinopathy. Patients on dialysis, HBA1c more than 7.5, on lipid-lowering treatment, or with familial hyperlipidemia were excluded. Calculations were carried out using the SPSS v.10 statistical software.
Results
We found a significant positive correlation between Apo B levels and microvascular complications. Apo B was higher with overt nephropathy than incipient nephropathy (1.75 ±0.38), and higher in patients with incipient nephropathy (1.4± 0.48) than in patients without nephropathy (1.02 ± 0.34,
P
<0.01).
A highly significant correlation was detected between the grades of retinopathy and the Apo B level. Finally, a significant positive correlation was detected between the presence of maculopathy and Apo B. Apo B levels were significantly higher in the presence of both nephropathy and retinopathy (1.26 ± 0.389) than in the absence of both complications (0.77± 0.361,
P
<0.05).
Conclusion
Apo B levels are strongly correlated to diabetic microvascular complications. The higher the degree of nephropathy, the higher the Apo B level. The presence of more than one microvascular complication correlates positively with high levels of Apo B. This suggests the possible use of Apo B as a sensitive biomarker of the presence of early diabetic microvascular complications.</description><identifier>ISSN: 1110-7782</identifier><identifier>EISSN: 2090-9098</identifier><identifier>DOI: 10.7123/01.EJIM.0000432236.92356.43</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Apolipoproteins ; Creatinine ; Diabetes ; Diabetic nephropathy ; Internal Medicine ; Lipoproteins ; Medicine & Public Health ; Metabolic disorders ; Original Article</subject><ispartof>The Egyptian journal of internal medicine, 2013-09, Vol.25 (3), p.137-142</ispartof><rights>The Egyptian Society of Internal Medicine 2013</rights><rights>The Egyptian Society of Internal Medicine 2013. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2443-b27ff6a50d29001a5f0a33262802dd53d4f06e9690113ea24e341e702e5acfa83</citedby><cites>FETCH-LOGICAL-c2443-b27ff6a50d29001a5f0a33262802dd53d4f06e9690113ea24e341e702e5acfa83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2790043903/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2790043903?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25744,27915,27916,37003,44581,74887</link.rule.ids></links><search><creatorcontrib>Rizk, Mary N.</creatorcontrib><creatorcontrib>Aly, Hala</creatorcontrib><creatorcontrib>Samir, Pierre</creatorcontrib><creatorcontrib>Mofty, Hala el</creatorcontrib><creatorcontrib>Allah, Osama K.</creatorcontrib><title>Apolipoprotein B level and diabetic microvascular complications: is there a correlation?</title><title>The Egyptian journal of internal medicine</title><addtitle>Egypt J Intern Med</addtitle><description>Introduction
Dyslipidemia has long been implicated in diabetic complications. However, many subgroups have been considered to be responsible. Furthermore, a cause and effect relationship has long been debated. Apolipoprotein B (Apo B) is an exact measure of the total number of very low-density lipoprotein and low-density lipoprotein particles; thus, total plasma Apo B is a reliable surrogate for actual low-density lipoprotein particle number irrespective of its size. Hence, it is a better indicator of the correlation between dyslipidemia and diabetic microvascular complications.
Aim of the work
Our aim is to study the correlation between Apo B and diabetic microvascular complications, namely, nephropathy and retinopathy.
Materials and methods
A cross sectional study was carried out of 56 diabetic patients, 36 men and 20 women, both type 1 and 2, who were chosen randomly from the outpatient Endocrinology Clinic in Cairo University. Serum creatinine, estimated glomerular filtration rate, urine albumin/ creatinine ratio (A/C ratio), and Apo B levels were determined. Groups were divided according to the A/C ratio as follows: no proteinuria (A/C ratio<30mg/g), incipient proteinuria (30–300mg/g), and overt proteinuria (>300mg/g). We performed fundus examination as well as fluorescein angiography in patients with retinopathy. Patients on dialysis, HBA1c more than 7.5, on lipid-lowering treatment, or with familial hyperlipidemia were excluded. Calculations were carried out using the SPSS v.10 statistical software.
Results
We found a significant positive correlation between Apo B levels and microvascular complications. Apo B was higher with overt nephropathy than incipient nephropathy (1.75 ±0.38), and higher in patients with incipient nephropathy (1.4± 0.48) than in patients without nephropathy (1.02 ± 0.34,
P
<0.01).
A highly significant correlation was detected between the grades of retinopathy and the Apo B level. Finally, a significant positive correlation was detected between the presence of maculopathy and Apo B. Apo B levels were significantly higher in the presence of both nephropathy and retinopathy (1.26 ± 0.389) than in the absence of both complications (0.77± 0.361,
P
<0.05).
Conclusion
Apo B levels are strongly correlated to diabetic microvascular complications. The higher the degree of nephropathy, the higher the Apo B level. The presence of more than one microvascular complication correlates positively with high levels of Apo B. This suggests the possible use of Apo B as a sensitive biomarker of the presence of early diabetic microvascular complications.</description><subject>Apolipoproteins</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Diabetic nephropathy</subject><subject>Internal Medicine</subject><subject>Lipoproteins</subject><subject>Medicine & Public Health</subject><subject>Metabolic disorders</subject><subject>Original Article</subject><issn>1110-7782</issn><issn>2090-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqNkE9Lw0AQxRdRsNR-h4WeE2f_JVkVpJaqlYoXBW_LNpnoSprE3bTgtzdphV6dyxzeezO8HyFTBnHKuLgEFi-els8x9CMF5yKJNRcqiaU4ISMOGiINOjslI8YYRGma8XMyCcGtQTHIlNIwIu-ztqlc27S-6dDV9I5WuMOK2rqghbNr7FxONy73zc6GfFtZT_Nm01Yut51r6nBFXaDdJ3qktle8x2ov3F6Qs9JWASd_e0ze7hev88do9fKwnM9WUc6lFNGap2WZWAUF1wDMqhKsEDzhGfCiUKKQJSSoEw2MCbRcopAMU-CobF7aTIzJ9HC3b_C9xdCZr2br6_6l4akeyGgQvev64OqLhOCxNK13G-t_DAMz0DTAzEDTHGmaPU0jh_TNIR36VP2B_vjjP_Ffv9l6Tg</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Rizk, Mary N.</creator><creator>Aly, Hala</creator><creator>Samir, Pierre</creator><creator>Mofty, Hala el</creator><creator>Allah, Osama K.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20130901</creationdate><title>Apolipoprotein B level and diabetic microvascular complications: is there a correlation?</title><author>Rizk, Mary N. ; Aly, Hala ; Samir, Pierre ; Mofty, Hala el ; Allah, Osama K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2443-b27ff6a50d29001a5f0a33262802dd53d4f06e9690113ea24e341e702e5acfa83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Apolipoproteins</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Diabetic nephropathy</topic><topic>Internal Medicine</topic><topic>Lipoproteins</topic><topic>Medicine & Public Health</topic><topic>Metabolic disorders</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rizk, Mary N.</creatorcontrib><creatorcontrib>Aly, Hala</creatorcontrib><creatorcontrib>Samir, Pierre</creatorcontrib><creatorcontrib>Mofty, Hala el</creatorcontrib><creatorcontrib>Allah, Osama K.</creatorcontrib><collection>SpringerOpen</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>The Egyptian journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rizk, Mary N.</au><au>Aly, Hala</au><au>Samir, Pierre</au><au>Mofty, Hala el</au><au>Allah, Osama K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apolipoprotein B level and diabetic microvascular complications: is there a correlation?</atitle><jtitle>The Egyptian journal of internal medicine</jtitle><stitle>Egypt J Intern Med</stitle><date>2013-09-01</date><risdate>2013</risdate><volume>25</volume><issue>3</issue><spage>137</spage><epage>142</epage><pages>137-142</pages><issn>1110-7782</issn><eissn>2090-9098</eissn><abstract>Introduction
Dyslipidemia has long been implicated in diabetic complications. However, many subgroups have been considered to be responsible. Furthermore, a cause and effect relationship has long been debated. Apolipoprotein B (Apo B) is an exact measure of the total number of very low-density lipoprotein and low-density lipoprotein particles; thus, total plasma Apo B is a reliable surrogate for actual low-density lipoprotein particle number irrespective of its size. Hence, it is a better indicator of the correlation between dyslipidemia and diabetic microvascular complications.
Aim of the work
Our aim is to study the correlation between Apo B and diabetic microvascular complications, namely, nephropathy and retinopathy.
Materials and methods
A cross sectional study was carried out of 56 diabetic patients, 36 men and 20 women, both type 1 and 2, who were chosen randomly from the outpatient Endocrinology Clinic in Cairo University. Serum creatinine, estimated glomerular filtration rate, urine albumin/ creatinine ratio (A/C ratio), and Apo B levels were determined. Groups were divided according to the A/C ratio as follows: no proteinuria (A/C ratio<30mg/g), incipient proteinuria (30–300mg/g), and overt proteinuria (>300mg/g). We performed fundus examination as well as fluorescein angiography in patients with retinopathy. Patients on dialysis, HBA1c more than 7.5, on lipid-lowering treatment, or with familial hyperlipidemia were excluded. Calculations were carried out using the SPSS v.10 statistical software.
Results
We found a significant positive correlation between Apo B levels and microvascular complications. Apo B was higher with overt nephropathy than incipient nephropathy (1.75 ±0.38), and higher in patients with incipient nephropathy (1.4± 0.48) than in patients without nephropathy (1.02 ± 0.34,
P
<0.01).
A highly significant correlation was detected between the grades of retinopathy and the Apo B level. Finally, a significant positive correlation was detected between the presence of maculopathy and Apo B. Apo B levels were significantly higher in the presence of both nephropathy and retinopathy (1.26 ± 0.389) than in the absence of both complications (0.77± 0.361,
P
<0.05).
Conclusion
Apo B levels are strongly correlated to diabetic microvascular complications. The higher the degree of nephropathy, the higher the Apo B level. The presence of more than one microvascular complication correlates positively with high levels of Apo B. This suggests the possible use of Apo B as a sensitive biomarker of the presence of early diabetic microvascular complications.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.7123/01.EJIM.0000432236.92356.43</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Apolipoproteins Creatinine Diabetes Diabetic nephropathy Internal Medicine Lipoproteins Medicine & Public Health Metabolic disorders Original Article |
| title | Apolipoprotein B level and diabetic microvascular complications: is there a correlation? |
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