Vitellogenin accumulation leads to reproductive senescence by impairing lysosomal function

The maintenance of proteostasis is essential for cellular and organism healthspan. How proteostasis collapse influences reproductive span remains largely unclear. In Caenorhabditis elegans , excess accumulation of vitellogenins, the major components in yolk proteins, is crucial for the development o...

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Published in:Science China. Life sciences 2023-03, Vol.66 (3), p.439-452
Main Authors: Tang, Jie, Ma, Yi-Cheng, Chen, Yuan-Li, Yang, Rui-Qiu, Liu, Heng-Chen, Wang, Xin, Ni, Baosen, Zou, Cheng-Gang, Zhang, Ke-Qin
Format: Article
Language:English
Subjects:
Aging
Animals
Autophagy
Biomedical and Life Sciences
Caenorhabditis elegans - metabolism
Caenorhabditis elegans Proteins - genetics
Life Sciences
Lysosomes - metabolism
Male
Mammals
Proteomes
Reproductive health
Research Paper
Semen - metabolism
Senescence
Vitellogenin
Vitellogenins - genetics
Vitellogenins - metabolism
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Summary:The maintenance of proteostasis is essential for cellular and organism healthspan. How proteostasis collapse influences reproductive span remains largely unclear. In Caenorhabditis elegans , excess accumulation of vitellogenins, the major components in yolk proteins, is crucial for the development of the embryo and occurs throughout the whole body during the aging process. Here, we show that vitellogenin accumulation leads to reproduction cessation. Excess vitellogenin is accumulated in the intestine and transported into the germline, impairing lysosomal activity in these tissues. The lysosomal function in the germline is required for reproductive span by maintaining oocyte quality. In contrast, autophagy and sperm depletion are not involved in vitellogenin accumulation-induced reproductive aging. Our findings provide insights into how proteome imbalance has an impact on reproductive aging and imply that improvement of lysosomal function is an effective approach for mid-life intervention for maintaining reproductive health in mammals.
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-022-2242-8