Pd-catalyzed exclusively regioselective [5 + 4] cycloaddition for the construction of 1,5-di/ox-azonanes

An efficient approach for the construction of 1,5-di/ox-azonanes via Pd-catalyzed [5 + 4] cycloaddition has been developed. This reaction could tolerate a variety of functional groups with exclusive regioselectivity, affording a series of nine-membered heterocycles in moderate to excellent yields. T...

Full description

Saved in:
Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2023-03, Vol.10 (7), p.1680-1685
Main Authors: Liu, Wenqi, Zang, Meng, Zhang, Jian, Wang, Quannan, Yang-Zi, Liu, Wei-Ping, Deng
Format: Article
Language:English
Subjects:
Cycloaddition
Functional groups
Organic chemistry
Palladium
Regioselectivity
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient approach for the construction of 1,5-di/ox-azonanes via Pd-catalyzed [5 + 4] cycloaddition has been developed. This reaction could tolerate a variety of functional groups with exclusive regioselectivity, affording a series of nine-membered heterocycles in moderate to excellent yields. The synthetic utility of the current method was also demonstrated by a gram-scale reaction.
ISSN:2052-4110
2052-4110
DOI:10.1039/d3qo00070b