Structure and Dynamics of the Number of Rat Bone-Marrow Hematopoetic Cells after the Introduction of Magnetoliposomes

The use of magnetite nanoparticles in biology and medicine is steadily growing, while some questions regarding their safety remain unclear. For example, nanomagnetite-based magnetoliposomes are a promising basis for the creation of new drugs. In this work, using hematological methods, a comparative...

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Published in:Cell and tissue biology 2023-02, Vol.17 (1), p.74-82
Main Authors: Milto, I. V., Shevtsova, N. M., Ivanova, V. V., Serebryakova, O. N., Takhauov, R. M., Sukhodolo, I. V.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Body weight
Bone marrow
Cell Biology
Hematopoietic stem cells
Intravenous administration
Iron oxides
Life Sciences
Magnetite
Monocytes
Nanoparticles
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Summary:The use of magnetite nanoparticles in biology and medicine is steadily growing, while some questions regarding their safety remain unclear. For example, nanomagnetite-based magnetoliposomes are a promising basis for the creation of new drugs. In this work, using hematological methods, a comparative assessment of changes in the number of hematopoietic cells in the bone marrow in sexually mature outbred rats was carried out for 120 days after intravenous administration of a suspension of unmodified magnetite nanoparticles and magnetoliposomes based on them. The features of the structure of hematopoietic cells of the main differons of bone marrow (erythrocyte, granulocytic, lymphocytic, monocytic, and platelet) are described, as well as the dynamics of changes in their number during the experiment. Single intravenous administration of a suspension of magnetoliposomes based on magnetite nanoparticles at a dose of 0.14 g (Fe 3 O 4 ) per 1 kg of body weight (injection volume 3 mL) does not cause changes in the structure and number of hematopoietic cells of the studied rat bone-marrow differons. The absence of a negative effect of magnetoliposomes based on magnetite nanoparticles on the structure of hematopoietic cells of the bone marrow allows us to consider these nanostructures as a promising magnetically controlled carrier for creating modern systems for the targeted delivery of diagnostic and therapeutic drugs.
ISSN:1990-519X
1990-5203
DOI:10.1134/S1990519X23010078