A Food‐Effect Study to Evaluate the Oral Bioavailability of Desidustat

This randomized, single‐treatment, 2‐sequence study evaluated the food effect on oral bioavailability of desidustat. Healthy adult male and female subjects were enrolled and randomly assigned to receive desidustat 50 mg orally in a fasting state in one period and a fed state in the other period. A s...

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Bibliographic Details
Published in:Clinical pharmacology in drug development 2023-04, Vol.12 (4), p.356-362
Main Authors: Patel, Hardik, Momin, Taufik, Kansagra, Kevinkumar, Patel, Harilal, Shah, Chintan, Barot, Ajaykumar, Bhavsar, Jay, Zala, Kuldipsinh, Parmar, Deven
Format: Article
Language:English
Subjects:
Adult
Bioavailability
Biological Availability
desidustat
Fasting
Female
Food
food effect
Food-Drug Interactions
healthy subjects
Humans
Male
pharmacokinetics
safety
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Summary:This randomized, single‐treatment, 2‐sequence study evaluated the food effect on oral bioavailability of desidustat. Healthy adult male and female subjects were enrolled and randomly assigned to receive desidustat 50 mg orally in a fasting state in one period and a fed state in the other period. A standardized high‐fat, high‐calorie breakfast was served to assess the food effect. The pharmacokinetic results showed that the time to maximum blood concentration of desidustat was delayed significantly (P 
ISSN:2160-763X
2160-7648
DOI:10.1002/cpdd.1206