Serum interleukin-6 as a predictor of the severity of coronavirus disease 2019

Background Inflammatory markers like interleukin-6 (IL-6) are linked to the worse outcome in coronavirus disease 2019 (COVID-19) cases. Other markers such as C-reactive protein are not as reliable as IL-6 in predicting respiratory failure. Aim To assess the function of IL-6 as a predictor of COVID-1...

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Published in:Research and Opinion in Anesthesia & Intensive Care 2023-01, Vol.10 (1), p.68-74
Main Authors: Ahmed, Islam, Hefny, Hesham, Ali, Amal, Refaie, Bahaa, Abdelal, Khalid, Taha, Elhaisam
Format: Article
Language:English
Subjects:
C-reactive protein
Coronaviruses
COVID-19
Cytokines
Interleukins
Medical research
Medicine, Experimental
Mortality
Respiratory failure
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Summary:Background Inflammatory markers like interleukin-6 (IL-6) are linked to the worse outcome in coronavirus disease 2019 (COVID-19) cases. Other markers such as C-reactive protein are not as reliable as IL-6 in predicting respiratory failure. Aim To assess the function of IL-6 as a predictor of COVID-19 severity. Patients and methods A total of 50 severe and critical patients with PCR-confirmed COVID-19 were included. All enrolled patients followed the case definition for confirmed cases of Egyptian national protocol for COVID-19 issued by MOHP. Clinical assessment, imaging, and laboratory data were recorded at admission. Pulmonary function was evaluated by SpO2/FiO2 ratio. Outcomes included hospital stay, prognosis of the disease, complications, death rate, and discharge, which were recorded during the follow-up. Results The elevated IL-6 group showed a significantly higher critical rate (87.1%) than the normal IL-6 group (26.3%) (P
ISSN:2356-9115
2356-9123
DOI:10.4103/roaic.roaic_22_22