Dietary Chromium Picolinate Supplementation Improves Glucose Utilization in Transition Calf by Ameliorating Insulin Response

The decrease in insulin sensitivity during the transition of preruminant calves into ruminant animals is the common denominator. Meanwhile, this adaptation predisposes dairy calves towards various health issues and metabolic disorders that occur in later life. Chromium (Cr) has been shown to potenti...

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Bibliographic Details
Published in:Biological trace element research 2023-06, Vol.201 (6), p.2795-2810
Main Authors: Khare, Shivam, Kumar, Muneendra, Kumar, Vinod, Kushwaha, Raju, Vaswani, Shalini, Kumar, Avinash, Yadav, Rajkumar Singh, Singh, Shanker Kumar, Singh, Yajuvendra, Shukla, Pankaj Kumar
Format: Article
Language:English
Subjects:
Animal Feed - analysis
Animals
average daily gain
Biochemistry
Biomedical and Life Sciences
Biotechnology
blood glucose
Blood Glucose - metabolism
blood serum
Body condition
Calves
Cattle
Chromium
Chromium - pharmacology
cortisol
Diarrhea
Diet
Diet - veterinary
Dietary Supplements
Esterification
Fatty acids
Fatty Acids, Nonesterified
Glucose
Glucose metabolism
Glucose tolerance
glucose tolerance tests
health status
Homeostasis
Hormones
Insulin
Insulin receptor substrate 1
insulin receptor substrate proteins
Insulin Resistance
Kinetics
Life Sciences
Metabolic disorders
Nutrition
Oncology
Receptors
risk
Risk reduction
Serum
Substrates
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Summary:The decrease in insulin sensitivity during the transition of preruminant calves into ruminant animals is the common denominator. Meanwhile, this adaptation predisposes dairy calves towards various health issues and metabolic disorders that occur in later life. Chromium (Cr) has been shown to potentiate insulin functioning and is thereby helpful in reducing the risk of these metabolic disorders. The aim of this study was to assess the effect of Cr supplementation on the insulin sensitivity and health status in Hariana calves during their transition period. A total of 24 preruminant Hariana calves were randomly allocated into four groups (6 calves per group) for a period of 90 days. Calves either received a basal diet devoid of supplemental Cr (control; Cr 0.0 group) or were supplemented with 0.05 mg (Cr 0.05 group), 0.10 mg (Cr 0.10 group), and 0.15 mg (Cr 0.15 group) of Cr per kg BW 0.75 as Cr-picolinate (Cr-Pic). To determine the effect of Cr supplementation on the insulin response, glucose-insulin-non-esterified fatty acids (NEFAs) kinetics was studied during the intravenous glucose tolerance test (IVGTT) and oral glucose tolerance test (OGTT). A rapid glucose disappearance ( p  
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-022-03405-1