Complementary strategies for synthesis of sulfinamides from sulfur-based feedstock

We describe a straightforward one-pot reductive protocol for the synthesis of sulfinamides from sulfonyl chlorides. This method enables the preparation of sulfinamides with a broad range of functional groups. Furthermore, we have expanded a known oxidative pathway to sulfinamides starting from thiol...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2023-04, Vol.21 (14), p.295-2954
Main Authors: Jabczun, Miloš, Nosek, Vladimír, Míšek, Ji í
Format: Article
Language:English
Subjects:
Functional groups
Raw materials
Structure-function relationships
Sulfur
Synthesis
Thiols
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Summary:We describe a straightforward one-pot reductive protocol for the synthesis of sulfinamides from sulfonyl chlorides. This method enables the preparation of sulfinamides with a broad range of functional groups. Furthermore, we have expanded a known oxidative pathway to sulfinamides starting from thiols. These methods together provide a general strategy for the synthesis of sulfinamides from common sulfur-based feedstock that is available with large structural and functional group diversity. We describe a straightforward one-pot reductive protocol for the synthesis of sulfinamides from sulfonyl chlorides.
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob00050h