Syntheses and Crystal Structures of Copper(II) and Zinc(II) Complexes Derived from 5-Bromo-2-((Cyclopropylimino)Methyl)Phenol with Antibacterial Activity

• Published in: Journal of structural chemistry 2023-03, Vol.64 (3), p.347-364
• Main Authors: Li, M., Qiu, X.-Y., Zheng, Z.-X., Wu, Y.-J.
• Format: Article
• Language: English
• Subjects: Atomic; Atomic/Molecular Structure and Spectra; Chemical analysis; Chemistry; Chemistry and Materials Science; Coordination; Copper; Crystal structure; Infrared spectroscopy; Inorganic Chemistry; Molecular; Optical and Plasma Physics; Physical Chemistry; Single crystals; Solid State Physics; Zinc compounds
• ISSN: 0022-4766; 1573-8779
• DOI: 10.1134/S0022476623030022

Four new complexes of copper(II) and zinc(II), [Cu 2 L 4 ] ( 1 ), [Cu 2 L 2 (N(CN) 2 ) 2 ] n ( 2 ), [Zn(HL) 2 I 2 ] ( 3 ) and [Zn(HL) 2 (NCS) 2 ] ( 4 ), where L is 5-bromo-2-((cyclopropylimino)methyl)phenolate, HL is the zwitterionic form of 5-bromo-2-((cyclopropylimino)methyl)phenol, were synthesized and characterized by elemental analysis and IR and UV-Vis spectroscopy. Structures of the complexes were further confirmed by single crystal X-ray structure determination. Complex 1 is a phenolate bridged dinuclear copper(II) compound, with the Cu atom in square pyramidal coordination. Complex 2 is a phenolate and dicyanamide bridged polynuclear copper(II) compound, with the Cu atom in square pyramidal coordination. Complexes 3 and 4 are mononuclear zinc(II) compounds, with the Zn atoms in tetrahedral coordination. The compounds were assayed for their antimicrobial activities. Complexes 1 and 2 have the most activities on B. subtilis , with MIC values of 1.2 μg/mL.